Evidence map›Paper›PMID 39716880›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Prenatal dexamethasone programs autonomic dysregulation in female rats.

Lakshmi Madhavpeddi, Monique Martinez, Jared Alvarez, Arpan Sharma, Chengcheng Hu, Stuart A Tobet, Taben M Hale

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Impacts of prenatal resiquimod exposure during late gestation on rat offspring development and behavior.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
  3. Programming the heart: prenatal glucocorticoids and sex-specific cardiovascular risk.American journal of physiology. Heart and circulatory physiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Lakshmi MadhavpeddiDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, United States.
Monique MartinezDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, United States.ORCID 0000-0002-6005-8509
Jared AlvarezDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, United States.
Arpan SharmaDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, United States.
Chengcheng HuDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States.ORCID 0000-0001-8525-0356
Stuart A TobetDepartment of Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States.ORCID 0000-0002-1615-7331
Taben M HaleDepartment of Basic Medical Sciences, University of Arizona College of Medicine, Phoenix, Arizona, United States.ORCID 0000-0002-5066-1216

Funding

Sex Differences in Major Depression, Part II: Impact of Prenatal Immune, Autonomic and Neurovascular FunctionU54MH118919 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI JILL M GOLDSTEIN · 2020 to 2026
$12.7M
Workforce inclusion in neuroscience through undergraduate research experienceR25NS107188 · NINDS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI VELAZQUEZ, RAMON · 2018 to 2022
$1.3M
HHS | NIH | National Institute of Mental Health (NIMH) U54 MH118919 S3HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 5R25NS107188-05NIMH NIH HHS U54 MH118919NINDS NIH HHS R25 NS107188
6 · The paper itself

Abstract

Autonomic dysfunction is associated with cardiovascular and neurological diseases, including hypertension, heart failure, anxiety, and stress-related disorders. Prior studies demonstrated that late gestation exposure to dexamethasone (DEX) resulted in female-biased increases in stress-responsive mean arterial pressure (MAP) and heart rate (HR), suggesting a role for glucocorticoid-mediated programming of autonomic dysfunction. The present study investigated the influence of sympathetic (SYM) or parasympathetic (PS) blockade on cardiovascular function in male and female rat offspring of mothers injected with DEX in utero [

Indexed as

Autonomic Nervous SystemDexamethasoneGlucocorticoidsHeart RateParasympathetic Nervous SystemPrenatal Exposure Delayed EffectsSympathetic Nervous SystemAnimalsArterial PressureFemaleMaleMuscarinic AntagonistsPregnancyRatsRats, Sprague-DawleyReceptors, Adrenergic, beta-1DexamethasoneGlucocorticoidsMuscarinic AntagonistsReceptors, Adrenergic, beta-1autonomicdevelopmentglucocorticoidprenatal programingsex differences

Identifiers

PMID39716880
PMCPMC12263084

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.