Evidence map›Paper›PMID 39716588›Full record

ArticleExperimental neurology2025

Microglial cell proliferation is regulated, in part, by reactive astrocyte ETB

John J McInnis, Matthew D LeComte, Leah F Reed, Emily E Torsney, Roxana Del Rio-Guerra, Matthew E Poynter, Jeffrey L Spees

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

John J McInnisDepartment of Medicine, Cardiovascular Research Institute, University of Vermont, Colchester, VT 05446, USA; Department of Neurological Sciences and Neuroscience Graduate Program, University of Vermont, Burlington, VT 05401, USA.
Matthew D LeComteDepartment of Medicine, Cardiovascular Research Institute, University of Vermont, Colchester, VT 05446, USA; Department of Neurological Sciences and Neuroscience Graduate Program, University of Vermont, Burlington, VT 05401, USA.
Leah F ReedDepartment of Medicine, Pulmonary Disease and Critical Care, University of Vermont, Burlington, VT 05405, USA.
Emily E TorsneyDepartment of Neurological Sciences and Neuroscience Graduate Program, University of Vermont, Burlington, VT 05401, USA.
Roxana Del Rio-GuerraHarry Hood Bassett Flow Cytometry and Cell Sorting Facility, University of Vermont, Burlington, VT 05401, USA.
Matthew E PoynterDepartment of Medicine, Pulmonary Disease and Critical Care, University of Vermont, Burlington, VT 05405, USA.
Jeffrey L SpeesDepartment of Medicine, Cardiovascular Research Institute, University of Vermont, Colchester, VT 05446, USA; Department of Neurological Sciences and Neuroscience Graduate Program, University of Vermont, Burlington, VT 05401, USA. Electronic address: Jeffrey.Spees@uvm.edu.

Funding

Vascular protection by HGF/IgG protein complexes that activate RYKR01HL132264 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPEES, JEFFREY L · 2016 to 2019
$1.5M
Control of reactive astrocytes by Notch1 and Amyloid Precursor ProteinR01NS073815 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI SPEES, JEFFREY L · 2012 to 2015
$1.3M
VasaPlex-based biologics for treatment of reperfusion injury after myocardial infarctionR41HL162161 · NHLBI · SAMBA BIOLOGICS INCORPORATED · PI SPEES, JEFFREY L · 2022 to 2022
$498k
NHLBI NIH HHS R01 HL132264NHLBI NIH HHS R41 HL162161NINDS NIH HHS R01 NS073815
6 · The paper itself

Abstract

Reciprocal communication between reactive astrocytes and microglial cells provides local, coordinated control over critical processes such as neuroinflammation, neuroprotection, and scar formation after CNS injury, but is poorly understood. The vasoactive peptide hormone endothelin (ET) is released and/or secreted by endothelial cells, microglial cells and astrocytes early after ischemic stroke and other forms of brain injury. To better understand glial cell communication after stroke, we sought to identify paracrine effectors produced and secreted downstream of astroglial endothelin receptor B (ETB

Indexed as

AstrocytesCell ProliferationIschemic StrokeMicrogliaReceptor, Endothelin BSignal TransductionAnimalsCells, CulturedMaleMiceMice, Inbred C57BLMice, TransgenicReceptor, Endothelin BAngiopoietinEndothelinMicrogliaParacrineReactive astrocyteStroke

Identifiers

PMID39716588
PMCPMC11781953

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.