Evidence map›Paper›PMID 39716326›Full record

ArticleBMC research notes2024

Treatment initiation and completion among head and neck squamous cell carcinoma patients in Tanzania.

Mary Jue Xu, Sumaiya Haddadi, Beatrice Paul Mushi, Li Zhang, Godfrey Sama, Sarah Kutika Nyagabona, Dianna Ng, Sikudhani Muya, Atuganile Edward Malango, Enica Richard and 6 more

Abstract read
In one paragraph

Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Time to Measure: A Proposed Theoretical Model for Head and Neck Cancer Intervals of Care.World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mary Jue XuDepartment of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, United States of America. maryjue.xu@ucsf.edu.
Sumaiya HaddadiMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Beatrice Paul MushiMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Li ZhangDepartment Epidemiology and Biostatistics, Department of Medicine, University of California San Francisco, San Francisco, United States of America.
Godfrey SamaMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Sarah Kutika NyagabonaMuhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Dianna NgDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, United States of America.
Sikudhani MuyaDepartment of Radiation Oncology, Ocean Road Cancer Institute, Dar es Salaam, Tanzania.
Atuganile Edward MalangoDepartment of Anatomic Pathology, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Enica RichardDepartment of Otorhinolaryngology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Patrick HaDepartment of Otolaryngology-Head and Neck Surgery, University of California San Francisco, San Francisco, United States of America.
Sue S YomDepartment of Radiation Oncology, University of California San Francisco, San Francisco, United States of America.
Willybroad MassaweDepartment of Otorhinolaryngology, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Elia J MmbagaDepartment of Epidemiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Katherine Van Loon *Department of Medicine, Division of Hematology/Oncology, University of California San Francisco, San Francisco, United States of America.
Aslam Nkya *Department of Otorhinolaryngology, Muhimbili National Hospital, Dar es Salaam, Tanzania.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
A multi-faceted intervention to promote breast cancer hormone receptor testing in TanzaniaK08CA263299 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI Dianna L. Ng · 2021 to 2026
$1.3M
National Institutes of Health, United States K08CA263299NCI NIH HHS K08 CA263299NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

objectiveFew studies characterizing clinical outcomes of head and neck cancer (HNC) patients in sub-Saharan Africa report the proportion of patients who initiate and complete treatment, information integral to contextualizing survival outcomes. This retrospective cohort study describes HNC patients who presented to Muhimbili National Hospital and Ocean Road Cancer Institute in 2018, the highest-volume oncology tertiary referral centers in Tanzania. Logistic regression was applied to assess predictors of treatment initiation and completion.

resultsAmong the 176 head and neck squamous cell carcinoma (HNSCC) patients, 34% (59) had no treatment documented, 34%(59) had documentation of treatment initiation but not completion, and 33%(58) had documentation of treatment completion based on the modalities started. Univariate logistic regression showed that late-stage disease was associated with increased odds of initiating treatment (OR 8.24, 95% CI 2.05-33.11, p = 0.003) and trends toward completing treatment (OR 7.41, 95% CI 0.90-60.99, p = 0.063). At last visit, 36.9%(65) were alive with a median follow up of 5.6 months (IQR 1.64-12.5 months). A large proportion of HNC patients who presented to MNH and ORCI did not initiate or complete treatment. These metrics are critical to contextualize care outcomes of HNC patients in resource-constrained health systems and develop interventions.

Indexed as

Head and Neck NeoplasmsSquamous Cell Carcinoma of Head and NeckAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesTanzaniaAfricaHead and neck cancerTanzaniaTreatment incompletion

Identifiers

PMID39716326
PMCPMC11668109

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.