Evidence map›Paper›PMID 39716324›Full record

ArticleSkeletal muscle2024

Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice.

Ram B Khattri, Abhinandan Batra, Zoe White, David Hammers, Terence E Ryan, Elisabeth R Barton, Pascal Bernatchez, Glenn A Walter

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ram B KhattriDepartment of Physiology and Aging, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-9991-263X
Abhinandan BatraDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA.ORCID 0000-0001-8207-1563
Zoe WhiteDepartment of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, and Centre for Heart + Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.
David HammersDepartment of Pharmacology & Therapeutics, University of Florida, Gainesville, FL, USA.
Terence E RyanDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Elisabeth R BartonDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA.
Pascal Bernatchez *Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, and Centre for Heart + Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada. pascal.bernatchez@ubc.ca.
Glenn A Walter *Department of Physiology and Aging, University of Florida, Gainesville, FL, USA. glennw@ufl.edu.ORCID 0000-0002-7346-2244

Funding

Understanding and Improving Therapies for the Muscular Dystrophies through Noninvasive BiomarkersP50AR052646 · NIAMS · UNIVERSITY OF FLORIDA · PI SWEENEY, H LEE · 2021 to 2024
$6.2M
CIHR PJT156060Mitacs IT13604NIAMS NIH HHS P50 AR052646Paul D. Wellstone Muscular Dystrophy Cooperative Research Center U54AR052646
6 · The paper itself

Abstract

Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most common model of Duchenne muscular dystrophy (DMD). By mimicking a human DMD-associated metabolic comorbidity, hyperlipidemia, in mdx mice by inactivating the apolipoprotein E gene (mdx-ApoE) we previously reported severe myofiber damage exacerbation via histology with large fibro-fatty infiltrates and phenotype humanization with ambulation dysfunction when fed a cholesterol- and triglyceride-rich Western diet (mdx-ApoE

Indexed as

LipidomicsMetabolomicsMice, Inbred mdxMuscle, SkeletalMuscular Dystrophy, DuchenneAnimalsApolipoproteins EDisease Models, AnimalLipid MetabolismLiverMaleMiceMice, Inbred C57BLApolipoproteins EDuchenneFibrofatty infiltrationHR-MASLiverMetabolismMuscleNMR

Identifiers

PMID39716324
PMCPMC11664822

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.