Evidence map›Paper›PMID 39716284›Full record

ArticleJournal of translational medicine2024

Novel approach to alleviate lupus nephritis: targeting the NLRP3 inflammasome in CD8

Yimei Lai, Lili Zhuang, Jieying Zhu, Shuang Wang, Chaohuan Guo, Binfeng Chen, Jin Li, Jia Shi, Mengyuan Li, Niansheng Yang and 1 more

Abstract read
In one paragraph

Article in Journal of translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. CD8Frontiers in immunology · 2026
    Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yimei Lai *Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Lili Zhuang *Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Jieying Zhu *Department of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Shuang WangDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Chaohuan GuoDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Binfeng ChenDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Jin LiDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Jia ShiDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Mengyuan LiDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China.
Niansheng YangDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China. zsuyns@163.com.ORCID 0000-0003-2624-5658
Mianjing ZhouDepartment of Rheumatology, The First Affiliated Hospital, Sun Yat-sen University, 58 Zhongshan Second Road, Guangzhou, 510080, P. R. China. zhoumj28@mail.sysu.edu.cn.ORCID 0000-0003-1386-7220

Funding

China Postdoctoral Science Foundation 2021M693661National Natural Science Foundation of China 81971519National Natural Science Foundation of China 82101884National Natural Science Foundation of China 82171770
6 · The paper itself

Abstract

backgroundRenal CD8

methodsNLRP3 inflammasome activity in renal CD8

resultsActivation of the NLRP3 inflammasome was confirmed in renal CD8

conclusionsNLRP3 inflammasome activity in renal CD8

Indexed as

Antigens, CDCD8-Positive T-LymphocytesInflammasomesIntegrin alpha ChainsLupus NephritisNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsAntigens, Differentiation, T-LymphocyteCD69 AntigensCD8 AntigensFemaleFuransHumansImmunologic MemoryIndenesKidneyalpha E integrinsAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensCD8 AntigensFuransIndenesInflammasomesIntegrin alpha ChainsLectins, C-TypeN-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamideNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinSulfonamidesSulfonesCD8+ tissue-resident memory cellsIL-1βLupus nephritisNLRP3 inflammasome

Identifiers

PMID39716284
PMCPMC11668076

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.