ArticleLipids in health and disease2024
Association of visceral adiposity index and lipid accumulation product with frailty in U.S. adults: a cross-sectional study from NHANES.
Article in Lipids in health and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Deciphering the obesity paradox in phenotypic age acceleration through thyroid hormone sensitivity: results from NHANES 2007-2010.Hormones (Athens, Greece) · 2026Article
- Metabolic score for visceral fat as a superior predictor of frailty in overweight and obese adults: a cross-sectional NHANES analysis (2007-2020).Diabetology & metabolic syndrome · 2025Article
- Visceral adiposity index, premature mortality, and life expectancy in US adults.Lipids in health and disease · 2025Article
- Association between overactive bladder and lipid accumulation product and visceral adiposity index: results from NHANES 2005-2018.Frontiers in medicine · 2025Article
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4 authors.
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Abstract
backgroundFrailty poses a considerable public health challenge because of its association with negative health consequences. Although obesity is recognized as a contributor to frailty, conventional measures fail to adequately account for the effects of visceral adiposity. The study aimed to investigate the associations between the visceral adiposity index (VAI) or lipid accumulation product (LAP) and frailty.
methodsThis study used data from the National Health and Nutrition Examination Survey (NHANES), which included 5,279 participants aged ≥ 20 years. The VAI and LAP were calculated via recognized formulas, and frailty was evaluated via a deficit accumulation approach. We employed logistic regression and restricted cubic splines to assess the associations among LAP, VAI and frailty.
resultsOut of 5,279 participants, 1,836 individuals were categorized as frail. According to the fully adjusted models, the highest VAI and LAP values were significantly associated with frailty, with adjusted ORs of 1.84 (95% CI: 1.40-2.42) and 2.47 (95% CI: 1.89-3.24), respectively, compared with the lowest values. A nonlinear relationship was identified between the LAP and frailty, with an inflection point of 1.589 (ln-transformed), whereas the VAI was linearly associated with frailty. Sensitivity analyses confirmed the robustness of these associations.
conclusionThe VAI and LAP are significantly related to frailty, highlighting the importance of visceral adiposity in frailty risk. These results increase the understanding of the metabolic underpinnings of frailty and may guide the development of targeted prevention strategies.
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