Evidence map›Paper›PMID 39716211›Full record

ArticleBMC biology2024

Functional characterization of the second feedback loop in the circadian clock of the Antarctic krill Euphausia superba.

Chiara Stefanelli, Davide Colaianni, Gabriella M Mazzotta, Gabriele Sales, Cristiano Bertolucci, Bettina Meyer, Alberto Biscontin, Cristiano De Pittà

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In one paragraph

Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Chiara StefanelliDepartment of Biology, University of Padova, Padova, 35121, Italy.
Davide ColaianniDepartment of Biology, University of Padova, Padova, 35121, Italy.
Gabriella M MazzottaDepartment of Biology, University of Padova, Padova, 35121, Italy.
Gabriele SalesDepartment of Biology, University of Padova, Padova, 35121, Italy.
Cristiano BertolucciDepartment of Life Sciences and Biotechnology, University of Ferrara, Ferrara, 44121, Italy.
Bettina MeyerInstitute for Chemistry and Biology of the Marine Environment, Carl Von Ossietzky University Oldenburg, Oldenburg, 26129, Germany.
Alberto BiscontinDepartment of Agricultural, Food, Environmental and Animal Sciences, University of Udine, Udine, 33100, Italy. alberto.biscontin@uniud.it.
Cristiano De PittàDepartment of Biology, University of Padova, Padova, 35121, Italy. cristiano.depitta@unipd.it.

Funding

Helmholtz Earth and Environment Research Program "Changing Earth - Sustaining our Future" Topic 6, Subtopic 6.2PRID 2023, University of Padova BIRD233738Programma Nazionale di Ricerche in Antartide - PNRA 2019_00065
6 · The paper itself

Abstract

backgroundThe Antarctic krill Euphausia superba is a keystone species in the Southern Ocean ecosystem. This crustacean has an ancestral clock whose main components have been identified and characterized in the past few years. However, the second feedback loop, modulating clock gene expression through two transcription factors, VRI and PDP1, has yet to be described. The presence of this second regulatory mechanism is suggested by the identification of its negative component, vrille, at the transcriptional level.

resultsHere, we describe the second feedback loop of krill by identifying the positive component, pdp1, and functionally characterizing both pdp1 and vrille. Starting from the online transcriptome database KrillDB

conclusionsThis study expands our knowledge about the molecular architecture of the Antarctic krill circadian clock by defining the components that take part in the modulation of clock expression, establishing a second feedback loop.

Indexed as

Circadian ClocksEuphausiaceaFeedback, PhysiologicalAnimalsAntarctic RegionsTranscription FactorsTranscription FactorsAntarctic krillCircadian clockEuphausia superbapdp1Second feedback loopvrille

Identifiers

PMID39716211
PMCPMC11668059

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.