Evidence map›Paper›PMID 39716203›Full record

Trial reportBMC medicine2024

Effectiveness and feasibility of a theory-informed intervention to improve Mediterranean diet adherence, physical activity and cognition in older adults at risk of dementia: the MedEx-UK randomised controlled trial.

A Jennings, O M Shannon, R Gillings, V Lee, R Elsworthy, R Bundy, G Rao, S Hanson, W Hardeman, S-M Paddick and 5 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03673722 (A Randomised Controlled Trial Investigating the Feasibility of a Multi-domain Intervention to Increase Mediterranean Diet), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03673722 nacompletednot on this map

A Randomised Controlled Trial Investigating the Feasibility of a Multi-domain Intervention to Increase Mediterranean Diet (MedDiet) Score and Physical Activity (PA) of Older UK Adults Who Are at Above Average Risk of Dementia

TypeinterventionalSponsorUniversity of East AngliaRan2019 to 2023Enrolled108ConditionsDementiaArmsFoods consistent with a MDP, Physical Activity, Control
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

A Jennings *Norwich Medical School, University of East Anglia, Norwich, UK.
O M Shannon *Human Nutrition & Exercise Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
R GillingsNorwich Medical School, University of East Anglia, Norwich, UK.
V LeeThe George Institute for Global Health, Barangaroo, NSW, Australia.
R ElsworthySchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
R BundyNorwich Medical School, University of East Anglia, Norwich, UK.
G RaoHuman Nutrition & Exercise Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
S HansonBehavioural and Implementation Science Group, School of Health Sciences, University of East Anglia, Norwich, UK.
W HardemanBehavioural and Implementation Science Group, School of Health Sciences, University of East Anglia, Norwich, UK.
S-M PaddickTranslational and Clinical Medicine, Newcastle University, Campus for Ageing and Vitality, Westgate Road, Newcastle Upon Tyne, UK.
M SiervoCurtin Dementia Centre of Excellence, enAble Institute, Curtin University, Perth, Australia.
S AldredSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
J C MathersHuman Nutrition & Exercise Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
M HornbergerNorwich Medical School, University of East Anglia, Norwich, UK.
A M MinihaneNorwich Medical School, University of East Anglia, Norwich, UK. a.minihane@uea.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite an urgent need for multi-domain lifestyle interventions to reduce dementia risk, there is a lack of interventions which are informed by theory- and evidence-based behaviour change strategies, and no interventions in this domain have investigated the feasibility or effectiveness of behaviour change maintenance. We tested the feasibility, acceptability and cognitive effects of a personalised theory-based 24-week intervention to improve Mediterranean diet (MD) adherence alone, or in combination with physical activity (PA), in older-adults at risk of dementia, defined using a cardiovascular risk score.

methodsParticipants (n = 104, 74% female, 57-76 years) were randomised to three parallel intervention arms: (1) control, (2) MD, or (3) MD + PA for 24 weeks and invited to an optional 24-week follow-up period with no active intervention. Behaviour change was supported using personalised targets, a web-based intervention, group sessions and food provision. The primary outcome was behaviour change (MD adherence and PA levels), and the secondary outcomes included feasibility and acceptability, cognitive function, cardiometabolic health (BMI and 24-h ambulatory blood pressure) and process measures.

resultsThe intervention was feasible and acceptable with the intended number of participants completing the study. Participant engagement with group sessions and food provision components was high. There was improved MD adherence in the two MD groups compared with control at 24 weeks (3.7 points on a 14-point scale (95% CI 2.9, 4.5) and 48 weeks (2.7 points (95% CI 1.6, 3.7)). The intervention did not significantly change objectively measured PA. Improvements in general cognition (0.22 (95% CI 0.05, 0.35), memory (0.31 (95% CI 0.10, 0.51) and select cardiovascular outcomes captured as underpinning physiological mechanisms were observed in the MD groups at 24 weeks.

conclusionsThe intervention was successful in initiating and maintaining dietary behaviour change for up to 12 months which resulted in cognitive benefits. It provides a framework for future complex behaviour change interventions with a range of health and well-being endpoints.

trial registrationClinicalTrials.gov NCT03673722.

Indexed as

CognitionDementiaDiet, MediterraneanExerciseAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPatient ComplianceTreatment OutcomeUnited KingdomBehaviour changeDementiaMediterranean dietPhysical activityRCT

Identifiers

PMID39716203
PMCPMC11667912

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.