Evidence map›Paper›PMID 39716121›Full record

Trial reportBMC pediatrics2024

Lung recruitment with HFOV versus VTV/AC in preterm infants with RDS.

Marwa Eldegwi, Ali Shaltout, Osama Elagamy, Dina Salama, Mohammed Elshaer, Basma Shouman

Abstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marwa EldegwiPediatrics and Neonatology Department, Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.
Ali ShaltoutPediatrics and Neonatology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Osama ElagamyPediatrics and Neonatology Department, Faculty of Medicine, Kafr El-Sheikh University, Kafr El-Sheikh, Egypt.
Dina SalamaPediatrics and Neonatology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Mohammed ElshaerDepartment of Clinical Pathology, Faculty of Medicine, Mansoura University, P.O. Box 35516, Mansoura, Egypt. Melshaer85@mans.edu.eg.ORCID https://orcid.org/0000-0002-0179-2869
Basma ShoumanPediatrics and Neonatology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo compare the effect of lung recruitment using high frequency ventilation versus volume targeted ventilation on duration of intubation as well as its effect on lung inflammation in preterm infants with respiratory distress syndrome.

methodsThe study was conducted on a total of 40 preterm infants, 34 weeks gestational age or less, having RDS that needed intubation and mechanical ventilation within the first 72 h after their birth at the NICU of Mansoura University Children's Hospital during the period from July 2020 to July 2022. Infants included were randomly assigned into two groups, Group A who were subjected to LRM using HFOV (20 cases) and Group B who were subjected to LRM using VTV/AC (20 cases). TGF-β1 level was measured in BAL samples of all studied infants at two time points; before lung recruitment maneuver and at day 5 after lung recruitment or just before extubation if extubation occurs earlier than 5 days.

resultsLung recruitment maneuver had no significant effect on time to extubation. Both groups showed no significant difference in rate of prematurity complications nor delta change of TFG-β1 level in tracheal aspirate of those preterm infants measured before lung recruitment and five days after recruitment or at extubation when extubation occurred earlier.

conclusionsLung recruitment maneuver was not associated with significant difference between both groups of preterm infants. The results obtained from our study, being the first of its kind to compare the effect of lung recruitment, provide a promising research area for further investigations.

Indexed as

High-Frequency VentilationInfant, PrematureRespiratory Distress Syndrome, NewbornBronchoalveolar Lavage FluidFemaleHumansInfant, NewbornIntubation, IntratrachealMaleRespiration, ArtificialTransforming Growth Factor beta1Transforming Growth Factor beta1Bronchoalveolar lavageIntensive care unitsNeonatalRespiratory distress syndrome

Identifiers

PMID39716121
PMCPMC11665117

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.