Evidence map›Paper›PMID 39715904›Full record

ArticleTranslational stroke research2025

The Impact of Postprocedural Anticoagulant Use in Patients Undergoing Woven EndoBridge: A Multicenter Propensity Score-Matched Study.

Basel Musmar, Hamza Adel Salim, Joanna M Roy, Nimer Adeeb, Antony A Fuleihan, Elias Atallah, Saman Sizdahkhani, Sravanthi Koduri, Spyridon Karadimas, Bachar El Baba and 29 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Basel MusmarDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Hamza Adel SalimDepartment of Neuroradiology, MD Anderson Medical Center, Houston, TX, USA.
Joanna M RoyDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Nimer AdeebDepartment of Neurosurgery and Radiology, Louisiana State University Health Science Center, Shreveport, LA, USA.
Antony A FuleihanDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Elias AtallahDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Saman SizdahkhaniDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Sravanthi KoduriDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Spyridon KaradimasDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Bachar El BabaDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Brian M HowardDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Jonathan A GrossbergDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Kyle W ScottDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
Jan-Karl BurkhardtDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
Visish M SrinivasanDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
Fernanda ErazuLyerly Neurosurgery, Baptist Health System, Jacksonville, Jacksonville, FL, USA.
Ricardo A HanelLyerly Neurosurgery, Baptist Health System, Jacksonville, Jacksonville, FL, USA.
Abdelaziz AmllayDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Charles MatoukDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Andrew MacNeilDepartment of Neurosurgery, University of Florida, Gainesville, FL, USA.
Nohra ChalouhiDepartment of Neurosurgery, University of Florida, Gainesville, FL, USA.
Santiago Gomez-PazDepartment of Neurosurgery, University of Utah, Salt Lake City, USA.
Ramesh GrandhiDepartment of Neurosurgery, University of Utah, Salt Lake City, USA.
Vinay JaikumarDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Elad LevyDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Adnan SiddiquiDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Max KlaimanDepartment of Neurosurgery, Abbott Northwestern Hospital, Minneapolis, MN, USA.
Josser DelgadoDepartment of Neurosurgery, Abbott Northwestern Hospital, Minneapolis, MN, USA.
Haydn HoffmanDepartment of Neurosurgery, Semmes-Murphey Clinic and University of Tennessee Health Sciences Center, Memphis, TN, USA.
Adam ArthurDepartment of Neurosurgery, Semmes-Murphey Clinic and University of Tennessee Health Sciences Center, Memphis, TN, USA.
David M HasanDepartment of Neurosurgery, Duke University, Durham, NC, USA.
Christina NotarianniDepartment of Neurosurgery and Radiology, Louisiana State University Health Science Center, Shreveport, LA, USA.
Hugo H CuellarDepartment of Neurosurgery and Radiology, Louisiana State University Health Science Center, Shreveport, LA, USA.
Bharat GuthikondaDepartment of Neurosurgery and Radiology, Louisiana State University Health Science Center, Shreveport, LA, USA.
Jacques MorcosDepartment of Neurosurgery, McGovern Medical School, UT Health Sciences Center at Houston, Houston, TX, USA.
Stavropoula I TjoumakarisDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Michael Reid GoochDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Robert H RosenwasserDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA.
Pascal JabbourDepartment of Neurological Surgery, Thomas Jefferson University Hospital, 901 Walnut street 3rd Floor, Philadelphia, PA, 19107, USA. pascal.jabbour@jefferson.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Woven EndoBridge (WEB) device has become a prominent treatment for wide-neck bifurcation intracranial aneurysms since its FDA approval in 2018. However, the impact of anticoagulant therapy on its efficacy and patient outcomes remains underexplored. This study aims to evaluate the effects of postoperative anticoagulant use on aneurysm occlusion, retreatment rates, and functional outcomes following WEB device implantation. This retrospective multicenter study included 457 patients treated with the WEB device across 10 academic institutions in the United States between January 2012 and June 2024. Patients were categorized based on postoperative anticoagulant use: 91 patients (19.9%) received anticoagulants, while 366 patients (80.1%) did not. Propensity score matching (PSM) was employed to control for potential confounders, resulting in 316 matched patients (229 non-anticoagulant and 87 anticoagulant). After PSM, the anticoagulant group had lower rates of excellent functional outcomes (mRS 0-1: 73% vs. 85%, p = 0.026) and higher mortality rates (6.7% vs. 3.7%, p = 0.33), though the latter difference was not statistically significant. No significant differences in the last follow-up adequate occlusion were observed between the two groups (p = 0.7). However, patients in the anticoagulant group had lower major device compaction (> 50%) (4.9% vs. 12%, p = 0.12) and retreatment rates (4.6% vs. 12%, p = 0.045). Postoperative anticoagulant use is associated with poor functional outcomes and higher tendency for higher mortality rate. No significant differences in the last follow-up adequate occlusion rate were observed between the anticoagulant group and non-anticoagulant group. However, patients in the anticoagulant group had lower major compaction and retreatment rates. These findings suggest that the WEB mechanism of occlusion is more complex than what have been hypothesized and highlight the need for individualized management strategies to optimize outcomes in patients requiring anticoagulation post-WEB. Further studies are needed.

Indexed as

AnticoagulantsEndovascular ProceduresIntracranial AneurysmAgedFemaleHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesTreatment OutcomeAnticoagulantsAneurysmAnticoagulantMulticenterPSMWEB

Identifiers

PMID39715904

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.