Evidence map›Paper›PMID 39715887›Full record

ArticleNature methods2025

Elucidating subcellular architecture and dynamics at isotropic 100-nm resolution with 4Pi-SIM.

Zijing Ouyang, Qian Wang, Xiaoyu Li, Qiuyang Dai, Muyuan Tang, Lin Shao, Wen Gou, Zijing Yu, Yanqin Chen, Bei Zheng and 10 more

Abstract read
In one paragraph

Article in Nature methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Zijing Ouyang *Biomedical Engineering Department, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, International Cancer Institute, Peking University, Beijing, China.ORCID http://orcid.org/0009-0009-3176-1471
Qian Wang *Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Xiaoyu Li *Institute of Medical Technology, Peking University Health Science Center, Beijing, China.
Qiuyang DaiSchool of Life Sciences, Westlake University, Hangzhou, China.
Muyuan TangSchool of Life Sciences, Westlake University, Hangzhou, China.
Lin ShaoDepartment of Neuroscience and Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-1905-4442
Wen GouInstitute of Medical Technology, Peking University Health Science Center, Beijing, China.
Zijing YuWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.ORCID http://orcid.org/0009-0005-1697-3872
Yanqin ChenWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Bei ZhengWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Linlin ChenWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Conghui PingWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Xiuli BiChongqing Key Laboratory of Image Cognition, College of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
Bin XiaoChongqing Key Laboratory of Image Cognition, College of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing, China.
Xiaochun YuWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Changliang LiuWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Liangyi ChenCenter for BioMed-X Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China. lychen@pku.edu.cn.ORCID http://orcid.org/0000-0003-1270-7321
Junchao FanChongqing Key Laboratory of Image Cognition, College of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing, China. fanjc@cqupt.edu.cn.ORCID http://orcid.org/0000-0003-2586-7973
Xiaoshuai HuangBiomedical Engineering Department, Institute of Advanced Clinical Medicine, State Key Laboratory of Molecular Oncology, International Cancer Institute, Peking University, Beijing, China. hxs@hsc.pku.edu.cn.ORCID http://orcid.org/0000-0002-0495-4720
Yongdeng ZhangWestlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China. zhangyongdeng@westlake.edu.cn.ORCID http://orcid.org/0000-0002-4569-8137

Funding

National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32150015National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32170691National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32227802National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32322049National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 32350009National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 62103071National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) 81925022National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund) T2288102
6 · The paper itself

Abstract

Three-dimensional structured illumination microscopy (3D-SIM) provides excellent optical sectioning and doubles the resolution in all dimensions compared with wide-field microscopy. However, its much lower axial resolution results in blurred fine details in that direction and overall image distortion. Here we present 4Pi-SIM, a substantial revamp of I

Indexed as

Imaging, Three-DimensionalMicroscopy, InterferenceAnimalsHumansMicroscopy, FluorescenceOrganellesTime-Lapse Imaging

Identifiers

PMID39715887
PMCPMC11810797

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.