ArticleNPJ precision oncology2024
Mutational disparities in colorectal cancers of White Americans, Alabama African Americans, And Oklahoma American Indians.
Hiroshi Y Yamada, Madhusmita Rout, Chao Xu, Philip H O'Neill, Farrukh Afaq, Katherine T Morris, Dharambir K Sanghera, Upender Manne, Chinthalapally V Rao
Abstract read
In one paragraphArticle in NPJ precision oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Hiroshi Y YamadaDepartment of Internal Medicine, Hematology/Oncology Section, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA. Hiroshi-Yamada@ouhsc.edu.ORCID http://orcid.org/0000-0002-0536-5581 Madhusmita RoutDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., Rm 317 BMSB, Oklahoma City, OK, USA.
Philip H O'NeillHarold Hamm Diabetes Center, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Farrukh AfaqDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Katherine T MorrisDepartment of Surgery, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Dharambir K SangheraDepartment of Pediatrics, College of Medicine, University of Oklahoma Health Sciences Center, 940 Stanton L. Young Blvd., Rm 317 BMSB, Oklahoma City, OK, USA.
Upender ManneDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. upendermanne@uabmc.edu.
Chinthalapally V RaoDepartment of Internal Medicine, Hematology/Oncology Section, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA. CV-Rao@ouhsc.edu.ORCID http://orcid.org/0000-0002-5715-7979 Funding
Proteomics CoreP20GM103447 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI David W Dyer · 2012 to 2026
$60.2MTissue Pathology Shared ResourceP30CA225520 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI ROBERT S. MANNEL · 2018 to 2026
$27.1MTRAINING AND CAREER DEVELOPMENTU54CA118948 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI UPENDER MANNE, Erica Michelle Stringer-Reasor · 2005 to 2026
$26.6MTUMOR RESISTANCE MECHANISMS TO ANTI-VEGF THERAPY IN PROSTATE CANCER (Sukyung Woo)P20GM103639 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DHANASEKARAN, DANNY N. · 2012 to 2022
$21.3MSafer Approaches to CRC ChemopreventionR01CA213987 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAO, CHINTHALAPALLY V. · 2017 to 2021
$2.4MAmerican Cancer Society (American Cancer Society, Inc.) MRSG 15-136-01-CCENCI NIH HHS P30 CA225520NCI NIH HHS R01 CA213987NCI NIH HHS U54 CA118948NIGMS NIH HHS P20 GM103447NIGMS NIH HHS P20 GM103639U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 5U54CA118948U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 9 R01 CA 213987-05S1U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) P20GM103639
6 · The paper itselfAbstract
The high incidence and mortality rates of colorectal cancer (CRC) in Alabama African Americans (AAs) and Oklahoma American Indians (AIs) are recognized as cancer disparities, yet the underlying causes have been poorly demonstrated. By evaluating CRC whole-exome sequencing and mutational profiles, here we report sets of mutated genes whose frequencies differed significantly (p < 0.05) in a race-specific manner. Secondary screening with cancer database identified "survival-critical genes (SCGs)" (i.e., genes whose mutations/alterations are associated with significant differences in the patients' survival rates) among the differentially mutated genes. Notable SCGs with race-pronounced variants were different from DEGs and their involved pathways included nucleotide catabolism and cell cycle checkpoints for AAs, and extracellular matrix organization for AIs. The inclusion of these SCGs with race-pronounced variants in the clinical CRC next-generation sequencing panels and the development of targeting drugs will serve as refinements for precision medicine to overcome racial disparities in health outcomes of CRC.
Identifiers
PMID39715885
PMCPMC11666716
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