ArticleThe Journal of antibiotics2025
Activity of cefiderocol in combination with tetracycline analogues against carbapenem-resistant Acinetobacter baumannii.
Article in The Journal of antibiotics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Resistance of Gram-Negative Bacteria to Eravacycline: A Systematic Review of Data from In Vitro Studies.Pathogens (Basel, Switzerland) · 2025Pooled it
- Eravacycline: From broad-spectrum coverage to novel clinical applications.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026Review
- Carbapenem Resistance inMicroorganisms · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic options for carbapenem-resistant Acinetobacter baumannii (CA-AB) are quite limited. Cefiderocol, a novel siderophore cephalosporin, has shown potent in vitro activity against CR-AB, and new tetracycline analogues such as eravacycline and omadacycline have been available in recent years. However, the synergism of cefiderocol with tetracycline analogues against CR-AB has not been well investigated. In this study, we evaluated the in vitro synergistic activity of cefiderocol in combination with tetracycline analogues (minocycline, tigecycline, eravacycline and omadacycline) against 48 clinical isolates of CR-AB by checkerboard methods and time-kill assays. Then we further verified the in vitro results with neutropenic murine thigh-infection models. Among 48 tested isolates tested with checkerboard methods, 35.4%, 33.3%, 50.0% and 37.5% showed synergistic interactions (FICI ≤ 0.5) in cefiderocol-minocycline combination, cefiderocol-tigecycline combination, cefiderocol-eravacycline combination and cefiderocol-omadacycline combination, respectively. None of the combinations exhibited any antagonistic interactions. In the time-kill assays, cefiderocol combined with tetracycline analogues showed synergistic effects in most isolates. Animal models found that combination therapy could reduce cell counts by nearly 2 log
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Registered trials
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