ArticleBDJ open2024
The oncogenic potential of salivary microRNA-93 and microRNA-412-3p in oral lichen planus: a case-control study.
Article in BDJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circulating microRNAs: a new era in early detection of oral squamous cell carcinoma (OSCC) - a systematic review and meta-analysis.Journal of the Egyptian National Cancer Institute · 2026Pooled it
- Salivary MicroRNAs as Innovative Biomarkers for Diagnosis and Prediction of the Oral Potentially Malignant Disorders Transition Towards Oral Cancer: A Systematic Review.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOral Lichen Planus is one of the most popular chronic mucocutaneous diseases. It is classified as potentially malignant lesions. Many microRNAs can be used as biological markers for the disease and for its malignant transformation. The aim of the study to measure the expression of microRNA-93 and microRNA-412-3p in Oral Lichen Planus patients, patients diagnosed as Oral Squamous Cell Carcinoma and healthy controls. METHODOLOGY: A total of 60 patients were divided into 3 groups; each group contains 20 patients. Group I for Oral Lichen Planus patients, group II for healthy controls and group III for Oral Squamous cell carcinoma patients. All of these patients were chosen from those attending Kasr Al-Einy hospital, Cairo University. After full diagnosis and matching of our eligibility criteria, saliva sample was taken from each patient to measure the concentration of microRNA-93 and microRNA-412-3p.
resultsBoth microRNA-93 and miceoRNA-412-3p were upregulated in Oral Squamous cell carcinoma patients than Oral Lichen patients than controls and both of them had great sensitivity, specificity and diagnostic accuracy for both Oral Lichen Planus and Oral Squamous cell carcinoma.
conclusionMicroRNA-93 and micriRNA-412-3p can be used as diagnostic markers and for the oncogenic potential of Oral Lichen Planus.
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Registered trials
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