ArticleNature communications2024
Broadscale dampening of uncertainty adjustment in the aging brain.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Distinct neural oscillations predict individual differences in feedback-guided cognitive flexibility.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- MEG state dynamics of sentence generation: evidence for a compensatory segmentation mechanism in healthy aging.Frontiers in computational neuroscience · 2026Article
- Slower transitions between control states lead to reductions in cognitive flexibility over the lifespan.bioRxiv : the preprint server for biology · 2025Article
- Locus coeruleus-related insula activation supports implicit learning.bioRxiv : the preprint server for biology · 2025Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to prioritize among input features according to relevance enables adaptive behaviors across the human lifespan. However, relevance often remains ambiguous, and such uncertainty increases demands for dynamic control. While both cognitive stability and flexibility decline during healthy ageing, it is unknown whether aging alters how uncertainty impacts perception and decision-making, and if so, via which neural mechanisms. Here, we assess uncertainty adjustment across the adult lifespan (N = 100; cross-sectional) via behavioral modeling and a theoretically informed set of EEG-, fMRI-, and pupil-based signatures. On the group level, older adults show a broad dampening of uncertainty adjustment relative to younger adults. At the individual level, older individuals whose modulation more closely resembled that of younger adults also exhibit better maintenance of cognitive control. Our results highlight neural mechanisms whose maintenance plausibly enables flexible task-set, perception, and decision computations across the adult lifespan.
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