Evidence map›Paper›PMID 39715724›Full record

ArticlePhysiological reports2024

Induction of cardiac alternans in human iPS-derived cardiomyocytes through β-adrenergic receptor stimulation.

Yuto Hinata, Daisuke Sasaki, Katsuhisa Matsuura, Tatsuya Shimizu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuto HinataOgino Memorial Laboratory, Nihon Kohden Corporation, TWIns, Shinjuku-ku, Tokyo, Japan.
Daisuke SasakiInstitute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
Katsuhisa MatsuuraInstitute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.
Tatsuya ShimizuInstitute of Advanced Biomedical Engineering and Science, TWIns, Tokyo Women's Medical University, Shinjuku-ku, Tokyo, Japan.ORCID 0000-0001-7601-4239

Funding

Japan Agency for Medical Research and Development (AMED) 22mk0101189h0102Japan Agency for Medical Research and Development (AMED) 23mk0101189h0103
6 · The paper itself

Abstract

Cardiac alternans (C-ALT) is a phenomenon of alternating strong and weak contractions in the heart and is considered a risk factor for the development of heart failure and arrhythmias. However, no model has been reported that can induce C-ALT in vitro using human cells, and the developmental mechanism of C-ALT has not been studied using human cells. In this study, we successfully induced C-ALT in vitro using human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). By stimulating β-adrenergic receptor with isoproterenol on hiPSC-CMs cultured in atmospheric condition (with ~0.04% CO

Indexed as

Adrenergic beta-AgonistsInduced Pluripotent Stem CellsIsoproterenolMyocytes, CardiacReceptors, Adrenergic, betaArrhythmias, CardiacCalciumCalcium SignalingCells, CulturedHumansMyocardial ContractionSarcoplasmic ReticulumAdrenergic beta-AgonistsCalciumIsoproterenolReceptors, Adrenergic, betacalcium alternanscardiac alternanscardiac contractilitycell sheet technologyhuman‐induced pluripotent stem cell‐derived cardiomyocytes

Identifiers

PMID39715724
PMCPMC11666346

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.