Evidence map›Paper›PMID 39715672›Full record

ArticleAJNR. American journal of neuroradiology2025

Perfusion Showdown: Comparison of Multiple MRI Perfusion Techniques in the Grading of Pediatric Brain Tumors.

Chang Y Ho, Nucharin Supakul, Greg Anthony, Qiuting Wen, Paula Chen, Maryann Allen, Jason G Parker, Benjamin R Gray, Eric Chen, Paul R Territo and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Chang Y HoFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana chang.ho@austin.utexas.edu.ORCID https://orcid.org/0000-0002-2358-1851
Nucharin SupakulFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.
Greg AnthonyFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.
Qiuting WenFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.ORCID https://orcid.org/0000-0002-7885-4036
Paula ChenFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.ORCID https://orcid.org/0000-0001-6039-0723
Maryann AllenFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.ORCID https://orcid.org/0009-0003-7453-2632
Jason G ParkerFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.
Benjamin R GrayFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.
Eric ChenDepartment of Medicine (E.C., P.R.T., S.A.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Paul R TerritoFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.
Scott A PersohnDepartment of Medicine (E.C., P.R.T., S.A.P.), Indiana University School of Medicine, Indianapolis, Indiana.
Stephen F KralikDepartment of Radiology (S.F.K.), Texas Children's Hospital, Houston, Texas.
Gary D HutchinsFrom the Department of Radiology and Imaging Sciences (C.Y.H., N.S., G.A., Q.W., P.C., M.A., J.G.P., B.R.G., P.R.T., G.D.H.), Indiana University School of Medicine, Indianapolis, Indiana.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeThere are multiple MRI perfusion techniques, with limited available literature comparing these techniques in the grading of pediatric brain tumors. For efficiency and limiting scan time, ideally only one MRI perfusion technique can be used in initial imaging. We compared DSC, dynamic contrast enhancement (DCE), and intravoxel incoherent motion (IVIM) along with ADC from DWI for differentiating high- versus low-grade pediatric brain tumors. MATERIALS AND

methodsPresurgical MRI at a single pediatric hospital for primary brain tumor of glial, neuronal, or embryonal origin including DWI, DSC, DCE, and IVIM with postsurgical histopathology results with World Health Organization (WHO) tumor grading were included. Tumor VOI was drawn on T2-weighted images registered to selected parametric maps from DWI, DSC, DCE, and IVIM. Multiple Bonferroni-corrected

resultsSeventy-two subjects were included with 36 low-grade and 36 high-grade tumors.

conclusionsPerfusion parameters from IVIM, DCE, and DSC were not able to significantly differentiate between high- versus low-grade pediatric brain tumors compared with ADC in our study. Fifth percentile ADC performed the best and can be the primary technique for grading pediatric brain tumors.

Indexed as

Brain NeoplasmsMagnetic Resonance AngiographyAdolescentChildChild, PreschoolDiffusion Magnetic Resonance ImagingFemaleHumansInfantMaleNeoplasm GradingReproducibility of ResultsSensitivity and Specificity

Identifiers

PMID39715672
PMCPMC12453422

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.