ArticleAmerican journal of veterinary research2025
Brain-type natriuretic peptide is a useful biomarker of cardiovascular disease and predictor of cardiac-related mortality in chimpanzees (Pan troglodytes).
Article in American journal of veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo validate the use of brain-type natriuretic peptide (BNP) for detecting and monitoring cardiac dysfunction in captive chimpanzees (Pan troglodytes).
methodsWe analyzed cross-sectional (N = 175) and longitudinal (N = 76) BNP, echocardiogram, ECG, and pathology data from living and deceased captive chimpanzees to examine age and sex effects and to assess the usefulness of BNP for detecting cardiovascular disease and predicting mortality. The study period was from July 2010 through October 2024.
resultsBrain-type natriuretic peptide values were significantly associated with age, and males exhibited significantly higher BNP values than females. Brain-type natriuretic peptide values were significantly heritable, with over half of variation in BNP being attributable to additive genetic effects. Chimpanzees with more severe cardiac scores based on echocardiograms and ECGs had significantly higher BNP values. Among 50 deceased chimpanzees, those with initial BNP values > 100 pg/mL were significantly more likely to have a cardiac-related causes of death than those with values < 100 pg/mL.
conclusionsBrain-type natriuretic peptide values reflected cardiac scores, and lower BNP values were associated with increased survival rates. Importantly, BNP values over a clinical threshold of 100 pg/mL were a significant predictor of cardiac death. CLINICAL RELEVANCE: Cardiovascular disease is a leading cause of morbidity and mortality in great apes, and sudden cardiac death with few to no preceding clinical signs is common in chimpanzees. A biomarker for occult heart disease could help identify individuals requiring monitoring or intervention. Brain-type natriuretic peptide is a useful biomarker for heart disease in chimpanzees, which has important clinical relevance for facilities that house captive chimpanzees.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.