ArticleNeurology2025
Brain Hypertrophy in Patients With Mesial Temporal Lobe Epilepsy With Hippocampal Sclerosis and Its Clinical Correlates.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Rethinking cortical hypertrophy in temporal lobe epilepsy.Brain : a journal of neurology · 2026Review
- Face-name associative memory in temporal lobe epilepsy: Region-specific insights in right-hemisphere onset.Epilepsy research · 2026Article
- Brain Structural Changes and Cognitive-Clinical Profiles in Late-Onset Unexplained Epilepsy.Neurology · 2026Article
- The Dual Associations of Peripheral Inflammatory Cells With Brain Reorganization in Insular Gliomas With/Without Epilepsy: An Exploratory Analysis.CNS neuroscience & therapeutics · 2026Article
- Distinct medial temporal volumetric signatures in extra-medial temporal lobe lesional epilepsy.Epilepsia open · 2026Article
- Voxel-based morphometry in mesial temporal lobe epilepsy surgery: an exploratory Moroccan pilot study.Frontiers in neuroscience · 2026Article
- Gray matter abnormalities and memory impairment in left mesial temporal lobe epilepsy.Frontiers in human neuroscience · 2025Article
- Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Correction to: Machine learning-based reconstruction of 2D MRI for quantitative morphometry in epilepsy.Imaging neuroscience (Cambridge, Mass.)Article
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17 authors.
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Abstract
BACKGROUND AND
objectivesMesial temporal lobe epilepsy (mTLE) is generally associated with focal brain atrophy, but little knowledge exists on possible disease-related hypertrophy of brain structures. We hypothesized that repeated seizures or adaptive plasticity may lead to focal brain hypertrophy and aimed to investigate associated clinical correlates.
methodsIn this cohort study, we included patients with mTLE undergoing detailed epilepsy evaluations and matched healthy volunteers (HVs) from 2 tertiary centers (discovery and validation cohorts). We assessed areas of brain hypertrophy and their clinical correlates using whole-brain voxel-based or surface-based morphometry (VBM, SBM), subcortical volumetry, and shape analysis of T1-weighted MRI data by fitting linear models. We evaluated the functional implications of the findings on memory encoding using fMRI.
resultsWe included 135 patients with mTLE with neuropathology-confirmed hippocampal sclerosis (77 left, 58 right; 82 women; mean age 37 ± 11 years) and 47 HVs (29 women, mean age 36 ± 11 years) in the discovery cohort. VBM detected increased gray matter volume of the contralateral amygdala in patients with both left ( DISCUSSION: Unilateral mTLE due to hippocampal sclerosis is associated with hypertrophy of the contralateral amygdala. This may represent plasticity to compensate for verbal memory deficits or may be the consequence of seizure spread to the contralateral hemisphere.
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