ArticleJournal of veterinary internal medicine
The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- 'Teleonomes in Tatters': The Welfare Costs of Selecting Dogs for Extreme Phenotypes, and the Case for Change.Animals : an open access journal from MDPI · 2026Article
- Genotypic Distribution ofGenes · 2026Article
- Dachshund spinal health by coat and size type.Journal of veterinary internal medicine · 2026Article
- Incorporating Morphological Evaluations into Breeding Soundness Examinations for Female Dogs.Animals : an open access journal from MDPI · 2025Review
- Case report: FGF4L1 retrogene insertion is lacking in the tall dachshund phenotype.Frontiers in veterinary science · 2024Article
- Erratum for "The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds".Journal of veterinary internal medicineArticle
- The relationship between radiographic disc calcification score and FGF4L2 genotype in dachshunds.Journal of veterinary internal medicineArticle
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe relationship between radiographic disc calcification score and FGF4L2 genotype has been reported in only a small number of dachshunds. HYPOTHESIS: A genotype with either 0 or 1 FGF4L2 copy will be associated with a lower number of calcified discs (lower K-n) compared with a genotype with 2 FGF4L2 copies. ANIMALS: Dachshunds registered with the Norwegian or Finnish Kennel Clubs for which both K-n and FGF4L2 genotype are known (n = 407).
methodsRetrospective study (2012-2024). The frequency and percentage of dachshunds within each K-n group (K0, K1/2, K3/4, K5+) by FGF4L2 genotype (FGF4L2/FGF4L2, N/FGF4L2, N/N) were reported. The K-n distribution differences among genotypes were analyzed by the Cochran-Mantel-Haenszel test in SAS 9.4. Significance was defined as P < .05.
resultsA difference in K-n distribution was found between dachshunds that have 0 or 2 FGF4L2 copies. However, no difference was found in the K-n distribution between dachshunds that have 1 or 2 FGF4L2 copies. CONCLUSIONS AND CLINICAL IMPORTANCE: Most dachshunds with 1 FGF4L2 copy have radiographic disc calcification scores that are associated with substantially lower risk of symptomatic disc disease. Radiographic disc calcification scores are similar in dachshunds with 0 and 1 FGF4L2 copies. Given the high allele frequency of FGF4L2, breeding to produce progeny with 1 FGF4L2 copy is expected to be a more achievable short-term goal for dachshund spinal health breeding programs than breeding for 0 copies. It is recommended that both K-n and FGF4L2 genotype status be considered when choosing dachshund breeding stock.
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