ArticleJournal of applied clinical medical physics2025
Patient-specific adaptive planning margin for whole bladder radiation therapy.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- CBCT-based online adaptive radiotherapy of the bladder - geometrical and dosimetrical considerations compared to conventional IGRT.Radiation oncology (London, England) · 2025Article
- Patient-specific adaptive planning margin for whole bladder radiation therapy.Journal of applied clinical medical physics · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhole bladder irradiation is an organ preservation treatment approach for muscle-invasive bladder cancer (MIBC). Conventional planning margins, typically 15-20 mm, increase normal tissue toxicity and limit possible dose escalation. PURPOSE: The study aimed to develop a patient-specific adaptive margin recipe for whole bladder irradiation to minimize the planning target volume (PTV) while preserving adequate dose coverage.
methodsSixteen patients who received whole-bladder irradiation were retrospectively selected for this study. We proposed a patient-specific anisotropic adaptive margin recipe, derived from the first five fractions of kV-CBCTs, to account for inter-fractional bladder changes. This recipe was validated using kV-CBCTs from fractions six to ten and the final five fractions. The goal was to achieve a residual volume, defined as the percentage of daily bladder volume (V
results(V
conclusionsThe proposed patient-specific adaptive margin recipe for whole bladder irradiation resulted in margins smaller than conventional ones, optimized normal tissue sparing, and maintained adequate PTV coverage.
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