ArticleAnnals of surgery2026
Fertility and Sexual Function in Males With Hirschsprung Disease: A Nordic Cross-sectional Study.
Article in Annals of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Updated European Reference Network for rare Inherited and Congenital Digestive and Gastrointestinal Anomalies guidelines for the management of rectosigmoid Hirschsprung's disease 2025.Journal of pediatric gastroenterology and nutrition · 2026Guideline
- Long-term effects of Hirschsprung disease in adults: meta-analysis and patient-level regression study.BJS open · 2025Pooled it
- Exploring potential sex differences in Hirschsprung disease: a national cohort study of diagnostic patterns and early postoperative outcome.Pediatric surgery international · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveTo assess fertility, sexual function, and sexual quality of life in males with Hirschsprung disease (HSCR) in the Nordic countries with a cross-sectional study using self-reported validated questionnaires.
backgroundData on fertility and sexual function in males with HSCR are limited.
methodsThis multicenter study targeted all males born between 1970 and 2003 who underwent pull-through surgery at a pediatric surgery center in Sweden, Denmark, Norway, or Finland. Participants completed a multidomain questionnaire. Demographic data were collected retrospectively from the medical records. Patients with trisomy 21 and other syndromes associated with intellectual disability were excluded. The main outcomes were fertility, sexual function, and sexual quality of life.
resultsA total of 169 patients (median age: 32 years) were included. Of 63 individuals attempting to father a biological child, 8 (12.7%) reported failure to conceive after 1 year, and 5 (7.9%) reported failure to conceive after 2 years. Our cohort did not report impaired fertility, a higher prevalence of erectile dysfunction, or lower sexual quality of life scores compared with normative summary data. Poor bowel function was associated with impaired fertility and erectile dysfunction ( P = 0.0278 and P = 0.0026, respectively). The length of the aganglionic segment and surgical method did not seem to affect fertility, sexual function, or sexual quality of life.
conclusionsMales with HSCR who have undergone pull-through surgery do not seem to report overall reduced fertility, higher prevalence of erectile dysfunction, or reduced sexual quality of life compared with estimates from the general population. Impaired bowel function may correlate with erectile dysfunction and impaired fertility in affected individuals.
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