Evidence map›Paper›PMID 39714730›Full record

ArticleJournal of medicinal chemistry2025

Discovery of an Orally Efficacious Pyrazolo[3,4-

Makafui Gasonoo, Soumitra Guin, José E Teixeira, Edmund Oboh, Anusha Gokanapalle, Peter Miller, Jonathan Oliva, Francis M Sverdrup, Christopher D Huston, Marvin J Meyers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Makafui GasonooDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Soumitra GuinDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.ORCID 0000-0002-8562-225X
José E TeixeiraDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont 05401, United States.
Edmund ObohDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Anusha GokanapalleDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.
Peter MillerDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont 05401, United States.
Jonathan OlivaDepartment of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, United States.
Francis M SverdrupDepartment of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, Missouri 63104, United States.
Christopher D HustonDepartment of Medicine, University of Vermont Larner College of Medicine, Burlington, Vermont 05401, United States.
Marvin J MeyersDepartment of Chemistry, School of Science and Engineering, Saint Louis University, Saint Louis, Missouri 63103, United States.ORCID 0000-0001-5484-619X

Funding

Repurposing the EMD-Serono "mini-library" for Cryptosporidium drug developmentR33AI141184 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUSTON, CHRISTOPHER D, MEYERS, MARVIN J · 2021 to 2023
$1.3M
Repurposing the EMD-Serono "mini-library" for Cryptosporidium drug developmentR21AI141184 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI GRIGGS, DAVID, HUSTON, CHRISTOPHER D · 2019 to 2020
$437k
Liquid chromatography and mass spectrometry instrument systemS10OD032206 · OD · SAINT LOUIS UNIVERSITY · PI SVERDRUP, FRANCIS MICHAEL · 2022 to 2022
$250k
NIAID NIH HHS R21 AI141184NIAID NIH HHS R33 AI141184NIH HHS S10 OD032206
6 · The paper itself

Abstract

Cryptosporidiosis is a diarrheal disease caused by the parasite

Indexed as

Boron CompoundsCryptosporidiosisPyrazolesPyrimidinesAdministration, OralAnimalsAntiprotozoal AgentsCryptosporidiumDrug DiscoveryHumansMiceStructure-Activity RelationshipAntiprotozoal AgentsBoron CompoundsPyrazolespyrazolo(3,4-d)pyrimidinePyrimidines

Identifiers

PMID39714730
PMCPMC12674823

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.