Evidence map›Paper›PMID 39714620›Full record

Observational studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

Hemorrhage risk after coblation tonsillectomy in Chinese pediatric: a multicenter, prospective, observational cohort study.

Hongming Xu, Shuyao Qiu, Jinxia Wang, Fugen Han, Zhongfang Xia, Liyan Ni, Jing Ma, Chunguang Chen, Xingqiang Gao, Junmei Zhang and 8 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05206799 (A Multi-centre Clinical Study of Hemorrhage Rate After Coblation Tonsillectomy in Children), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05206799 unknown statusnot on this map

A Multi-centre Clinical Study of Hemorrhage Rate After Coblation Tonsillectomy in Children

TypeobservationalSponsorShanghai Children's HospitalRan2022 to 2024Enrolled25,000ConditionsTonsillectomy, Child, Postoperative Hemorrhage
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Coblation power settings and postoperative recovery in children with obstructive sleep apnea.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Trial
  3. Sex-specific effects of surgical duration on peak pain after pediatric adenotonsillectomy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hongming Xu *Department of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, No.355, Luding Road, Shanghai, 200062, China.
Shuyao Qiu *Department of Pediatric Otorhinolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China.
Jinxia Wang *Clinical Research Unit, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Fugen HanDepartment of Otorhinolaryngology Head and Neck Surgery, The Affiliated Children's Hospital of Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou, China.
Zhongfang XiaDepartment of Otorhinolaryngology Head and Neck Surgery, Wuhan Children's Hospital, Wuhan, China.
Liyan NiDepartment of otolaryngology head and neck surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Jing MaDepartment of Otorhinolaryngology Head and Neck Surgery, Kunming Children's Hospital, Kunming, China.
Chunguang ChenDepartment of Otorhinolaryngology Head and Neck Surgery, Anyang Maternal and Child Health Hospital, Anyan, China.
Xingqiang GaoDepartment of Otorhinolaryngology Head and Neck Surgery, Xiamen Children's Hospital, Xiamen, China.
Junmei ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, Tianjin Children's Hospital, Tianjin, China.
Haixia LiuDepartment of Otorhinolaryngology, Shanxi Children's Hospital Shanxi Maternal and Child Health Hospital, Shanxi, China.
Haibing LiuDepartment of Otorhinolaryngology Head and Neck Surgery, Sichuan Provincial Maternity and Child Health Care Hospital, Chengdu, China.
Hongbing YaoMinistry of Education Key Laboratory of child Development and Disorders. Chongqing Key laboratory of Structural Birth defect and Reconstruction, Department of Otorhinolaryngology Head and Neck Surgery, National Clinical research Center for Child Health and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Qianger ZhuangDepartment of Otorhinolaryngology Head and Neck Surgery, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, Jiangsu, China.
Wei SongDepartment of Otorhinolaryngology Head and Neck Surgery, Dalian Women and Children's Medical Group, Dalian, China.
Sijun ZhaoDepartment of Otorhinolaryngology Head and Neck Surgery, Hunan Children's Hospital, Changsha, China.
Dabo LiuDepartment of Pediatric Otorhinolaryngology, Shenzhen Hospital, Southern Medical University, Shenzhen, China. daboliu@126.com.
Xiaoyan LiDepartment of Otorhinolaryngology Head and Neck Surgery, School of Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, No.355, Luding Road, Shanghai, 200062, China. lixiaoyanent@sina.com.ORCID http://orcid.org/0000-0003-3080-9321

Funding

the National Natural Science Foundation of China 82171121the Shanghai Sailing Program 22YF1437200
6 · The paper itself

Abstract

objectivesThe study aimed to assess the incidence of post-coblation tonsillectomy hemorrhage (PCTH) and identify associated risk factors in a pediatric Chinese population.

methodsThis prospective, multicenter cohort study, conducted over 17 months, included 8854 pediatric patients who underwent coblation tonsillectomy across 15 research centers in China. Patient data were collected through an Electronic Data Capture (EDC) system. The primary outcome was the incidence of PCTH within 21 days post-surgery. Secondary outcomes involved analyzing risk factors for PCTH using multivariable logistic regression.

resultsThe incidence of PCTH was 1.99%, with 176 patients experiencing hemorrhage. Significant risk factors included abnormal coagulation indicators (OR 10.56), longer surgery duration (OR 1.02), simultaneous adenoidectomy (OR 0.35), semi-liquid diet (OR 0.13), postoperative cough (OR 1.76), and the use of hemostatic agents (OR 1.58), intravenous antibiotics (OR 2.34), and painkillers (OR 2.33). Regional variations showed lower hemorrhage rates in East, Southwest, Central, and South China compared to North China.

conclusionsThe study found that the hemorrhage rate after coblation tonsillectomy is comparable to traditional tonsillectomy. Risk factors include coagulation status, surgical duration, and postoperative care. Regional differences in hemorrhage rates suggest the need for tailored approaches based on location. Coblation tonsillectomy is a safe and effective procedure for pediatric patients. TRIAL REGISTRATION NUMBER AND DATE OF REGISTRATION FOR PROSPECTIVELY REGISTERED TRIALS: This study was registered on Clinical trials.gov (NCT05206799), and approved by the Ethics Committee of Shanghai Children's Hospital, Shanghai Jiaotong University (2021R096-E01).

Indexed as

Postoperative HemorrhageTonsillectomyAdenoidectomyAdolescentChildChild, PreschoolChinaEast Asian PeopleFemaleHumansIncidenceInfantMaleOperative TimeProspective StudiesRisk FactorsCoblationMulticentrePediatricPost-coblation tonsillectomy hemorrhageTonsillectomy

Identifiers

PMID39714620

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.