Evidence map›Paper›PMID 39714488›Full record

ArticleHuman genetics2025

Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges.

Paola Turina, Giuditta Dal Cortivo, Carlos A Enriquez Sandoval, Emil Alexov, David B Ascher, Giulia Babbi, Constantina Bakolitsa, Rita Casadio, Piero Fariselli, Lukas Folkman and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Paola Turina *Department of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.
Giuditta Dal Cortivo *Department of Neurosciences, Biomedicine, and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134, Verona, Italy.
Carlos A Enriquez SandovalDepartment of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.
Emil AlexovDepartment of Physics and Astronomy, Clemson University, Clemson, SC, 29634, USA.
David B AscherComputational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Giulia BabbiDepartment of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.
Constantina BakolitsaDepartment of Plant and Microbial Biology and Center for Computational Biology, University of California, Berkeley, CA, USA.
Rita CasadioDepartment of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.
Piero FariselliDepartment of Medical Sciences, University of Torino, Turin, Italy.
Lukas FolkmanInstitute for Integrated and Intelligent Systems, Griffith University, Southport, QLD, Australia.
Akash KamandulaKhoury College of Computer Sciences, Northeastern University, Boston, MA, 02115, USA.
Panagiotis KatsonisDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Dong LiComputational Biology and Bioinformatics, Université Libre de Bruxelles, 50 Roosevelt Ave, 1050, Brussels, Belgium.
Olivier LichtargeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Pier Luigi MartelliDepartment of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.
Shailesh Kumar PandayDepartment of Physics and Astronomy, Clemson University, Clemson, SC, 29634, USA.
Douglas E V PiresSchool of Computing and Information Systems, The University of Melbourne, Melbourne, VIC, 3053, Australia.
Stephanie PortelliComputational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Fabrizio PucciComputational Biology and Bioinformatics, Université Libre de Bruxelles, 50 Roosevelt Ave, 1050, Brussels, Belgium.
Carlos H M RodriguesComputational Biology and Clinical Informatics, Baker Heart and Diabetes Institute, Melbourne, VIC, 3004, Australia.
Marianne RoomanComputational Biology and Bioinformatics, Université Libre de Bruxelles, 50 Roosevelt Ave, 1050, Brussels, Belgium.
Castrense SavojardoDepartment of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy.
Martin SchwersenskyComputational Biology and Bioinformatics, Université Libre de Bruxelles, 50 Roosevelt Ave, 1050, Brussels, Belgium.
Yang ShenDepartment of Electrical and Computer Engineering Texas, A&M University, College Station, TX, USA.
Alexey V StrokachDepartment of Computer Science, University of Toronto, Toronto, ON, Canada.
Yuanfei SunDepartment of Electrical and Computer Engineering Texas, A&M University, College Station, TX, USA.
Junwoo Woo, 3 Billion, Seoul, South Korea.
Predrag RadivojacKhoury College of Computer Sciences, Northeastern University, Boston, MA, 02115, USA.
Steven E BrennerDepartment of Plant and Microbial Biology and Center for Computational Biology, University of California, Berkeley, CA, USA.
Daniele Dell'OrcoDepartment of Neurosciences, Biomedicine, and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134, Verona, Italy. daniele.dellorco@univr.it.
Emidio CapriottiDepartment of Pharmacy and Biotechnology, University of Bologna, 40126, Bologna, Italy. emidio.capriotti@unibo.it.

Funding

Cognitive Computing of Alzheimer's Disease Genes and RiskU01AG068214 · NIA · BAYLOR COLLEGE OF MEDICINE · PI LICHTARGE, OLIVIER · 2021 to 2025
$4.4M
New Generation DelPhi: large systems and beyond electrostaticsR01GM093937 · NIGMS · CLEMSON UNIVERSITY · PI ALEXOV, EMIL GEORGIEV · 2010 to 2023
$4.3M
Center for Critical Assessment of Genome InterpretationU24HG007346 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BRENNER, STEVEN E, IOANNIDIS, NILAH MONNIER · 2020 to 2025
$3.8M
Unraveling molecular and system-level mechanisms of human disease-associated protein mutationsR35GM124952 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Yang Shen · 2017 to 2026
$2.9M
Component 2 - Resource ProjectU41HG007346 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BRENNER, STEVEN E · 2015 to 2017
$1.7M
DelPhi and associated resources: maintenance, development and applicationsR35GM151964 · NIGMS · CLEMSON UNIVERSITY · PI Emil Georgiev Alexov · 2024 to 2026
$1.1M
Critical Assessment of Genome Interpretation ConferenceR13HG006650 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BRENNER, STEVEN E · 2011 to 2018
$165k
Ministero dell'Istruzione, dell'Università e della Ricerca ELIXIRNextGenIT Grant Code IR0000010Ministero dell'Istruzione, dell'Università e della Ricerca PRIN-201744NR8SNational Health and Medical Research Council , Australia GNT1174405National Institute of Health, United States AG068214National Institute of Health, United States R01GM093937NHGRI NIH HHS R13 HG006650NHGRI NIH HHS U24 HG007346NHGRI NIH HHS U41 HG007346NIA NIH HHS U01 AG068214NIGMS NIH HHS R01 GM093937NIGMS NIH HHS R35 GM124952NIGMS NIH HHS R35 GM151964
6 · The paper itself

Abstract

Recent thermodynamic and functional studies have been conducted to evaluate the impact of amino acid substitutions on Calmodulin (CaM). The Critical Assessment of Genome Interpretation (CAGI) data provider at University of Verona (Italy) measured the melting temperature (T

Indexed as

Amino Acid SubstitutionCalmodulinAlgorithmsCircular DichroismHumansProtein StabilityThermodynamicsCalmodulin

Identifiers

PMID39714488
PMCPMC11975486

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.