Evidence map›Paper›PMID 39714343›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Striking Impact of Solvent Polarity on the Strength of Hydrogen-Bonded Complexes: A Nexus Between Theory and Experiment.

Rabindranath Lo, Debashree Manna, Jaroslav Vacek, Petr Bouř, Tao Wu, Zuzana Osifová, Ondřej Socha, Martin Dračínský, Pavel Hobza

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rabindranath LoInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Debashree MannaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Jaroslav VacekInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Petr BouřInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Tao WuInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Zuzana OsifováInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Ondřej SochaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Martin DračínskýInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.
Pavel HobzaInstitute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo námĕstí 542/2, 160 00, Prague, Czech Republic.ORCID https://orcid.org/0000-0001-5292-6719

Funding

Grantová Agentura České Republiky 22-15374SGrantová Agentura České Republiky 24-10558SREFRESH - Research Excellence for Region Sustainability and High-tech Industries CZ.10.03.01/00/22_003/0000048Univerzita Palackého v Olomouci IGA_PrF_2024_017
6 · The paper itself

Abstract

The binding free energy of hydrogen-bonded complexes is generally inversely proportional to the solvent dielectric constant. This occurs because the solvent-accessible surface area of the complex is always smaller than that of the individual subsystems, leading to a reduction in solvation energy. The present study explores the potential for stabilizing hydrogen-bonded complexes in a solvent with higher polarity. Contrary to the established understanding, we have demonstrated that the hydrogen-bonded complex (CH

Indexed as

Hydrogen bondingIRMetadynamicsMicro-solvationNMRONIOMSolvent effect

Identifiers

PMID39714343
PMCPMC11914941

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.