Evidence map›Paper›PMID 39714325›Full record

ArticleAngewandte Chemie (International ed. in English)2025

Pooled Nanoparticle Screening Using a Chemical Barcoding Approach.

Katherine Vaidya, Michael S Regan, James Lin, Jenna Houle, Aanchal Gupta, Sylwia A Stopka, Nathalie Y R Agar, Paula T Hammond, Natalie Boehnke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Pooled Nanoparticle Screening Using a Chemical Barcoding Approach.Angewandte Chemie (International ed. in English) · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Katherine VaidyaDepartment of Chemical Engineering and Materials Science, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Michael S ReganDepartment of Neurosurgery Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
James LinDepartment of Chemical Engineering and Materials Science, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Jenna HouleDepartment of Bioengineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Aanchal GuptaDepartment of Chemical Engineering and Materials Science, University of Minnesota Twin Cities, Minneapolis, MN, USA.
Sylwia A StopkaDepartment of Neurosurgery Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Nathalie Y R AgarDepartment of Neurosurgery Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Paula T HammondDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Natalie BoehnkeDepartment of Chemical Engineering and Materials Science, University of Minnesota Twin Cities, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-3468-2033

Funding

VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Jacqueline A. Lees · 1985 to 2026
$93.9M
TRD 3 - Enabling Technologies for Intraprocedural GuidanceP41EB028741 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI Oliver Jonas · 2021 to 2026
$10.7M
Understanding drug delivery through an integrated barcoding approachR00CA255844 · NCI · UNIVERSITY OF MINNESOTA · PI BOEHNKE, NATALIE · 2022 to 2024
$584k
Understanding drug delivery through an integrated barcoding approachK99CA255844 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BOEHNKE, NATALIE · 2021 to 2022
$308k
National Nanotechnology coordinated infrastructure ECCS-2025124National Science Foundation DMR-2011401NCI NIH HHS K99 CA255844NCI NIH HHS K99CA255844NCI NIH HHS P30 CA014051NCI NIH HHS P30-CA14051NCI NIH HHS R00 CA255844NCI NIH HHS R00CA255844NIBIB NIH HHS P41 EB028741NIBIB NIH HHS P41EB028741
6 · The paper itself

Abstract

We report the development of a small molecule-based barcoding platform for pooled screening of nanoparticle delivery. Using aryl halide-based tags (halocodes), we achieve high-sensitivity detection via gas chromatography coupled with mass spectrometry or electron capture. This enables barcoding and tracking of nanoparticles with minimal halocode concentrations and without altering their physicochemical properties. To demonstrate the utility of our platform for pooled screening, we synthesized a halocoded library of polylactide-co-glycolide (PLGA) nanoparticles and quantified uptake in ovarian cancer cells in a pooled manner. Our findings correlate with conventional fluorescence-based assays. Additionally, we demonstrate the potential of halocodes for spatial mapping of nanoparticles using mass spectrometry imaging (MSI). Halocoding presents an accessible and modular nanoparticle screening platform capable of quantifying delivery of pooled nanocarrier libraries in a range of biological settings.

Indexed as

NanoparticlesCell Line, TumorHumansPolylactic Acid-Polyglycolic Acid CopolymerPolylactic Acid-Polyglycolic Acid Copolymerbarcodinggas chromatographymass spectrometrynanoparticlespooled screening

Identifiers

PMID39714325
PMCPMC11773315

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.