Evidence map›Paper›PMID 39714242›Full record

ArticleACS chemical biology2025

PEGylated ATP-Independent Luciferins for Noninvasive High-Sensitivity High-Speed Bioluminescence Imaging.

Xiaodong Tian, Yiyu Zhang, Hui-Wang Ai

Abstract read
In one paragraph

Article in ACS chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaodong TianDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-9590-9943
Yiyu ZhangDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0001-8636-2827
Hui-Wang AiDepartment of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.ORCID 0000-0002-5664-3270

Funding

Next-Generation ATP-Independent Luciferases, Luciferins, and Bioluminescent Calcium IndicatorsR01EB035430 · NIBIB · UNIVERSITY OF VIRGINIA · PI Huiwang Ai · 2024 to 2026
$1.4M
NIBIB NIH HHS R01 EB035430
6 · The paper itself

Abstract

Bioluminescence imaging (BLI) is a powerful, noninvasive imaging method for animal studies. NanoLuc luciferase and its derivatives are attractive bioluminescent reporters recognized for their efficient photon production and ATP independence. However, utilizing them for animal imaging poses notable challenges. Low substrate solubility has been a prominent problem, limiting

Indexed as

Adenosine TriphosphateLuminescent MeasurementsAnimalsFirefly LuciferinLuciferasesLuminescent AgentsMicePolyethylene GlycolsAdenosine TriphosphateFirefly LuciferinLuciferasesLuminescent AgentsPolyethylene Glycols

Identifiers

PMID39714242
PMCPMC11744661

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.