Evidence map›Paper›PMID 39714210›Full record

ArticlemSystems2025

Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against

Dorota Kuc-Ciepluch, Karol Ciepluch, Daria Augustyniak, Grzegorz Guła, Barbara Maciejewska, Artur Kowalik, Ewelina Jop, Zuzanna Drulis-Kawa, Michał Arabski

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dorota Kuc-CiepluchDivision of Medical Biology, Jan Kochanowski University in Kielce, Kielce, Poland.
Karol CiepluchDivision of Medical Biology, Jan Kochanowski University in Kielce, Kielce, Poland.
Daria AugustyniakDepartment of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland.ORCID 0000-0002-0547-3937
Grzegorz GułaDepartment of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland.
Barbara MaciejewskaDepartment of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland.
Artur KowalikDivision of Medical Biology, Jan Kochanowski University in Kielce, Kielce, Poland.
Ewelina JopDepartment of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland.
Zuzanna Drulis-Kawa *Department of Pathogen Biology and Immunology, University of Wroclaw, Wroclaw, Poland.ORCID 0000-0002-4733-4660
Michał Arabski *Division of Medical Biology, Jan Kochanowski University in Kielce, Kielce, Poland.ORCID 0000-0002-9712-9286

Funding

Narodowe Centrum Nauki (NCN) 2017/27/B/NZ6/00199
6 · The paper itself

Abstract

Pyroptosis is an inflammatory immune response of eukaryotic cells to bacterial lipopolysaccharide (LPS) and other pathological stimuli, leading to the activation of the gasdermin D (GSDMD) and secretion of pore-forming domain GSDMD IMPORTANCE: Recombinant GSDMD

Indexed as

Anti-Bacterial AgentsBacteriophagesEndopeptidasesIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsPseudomonas aeruginosaPyroptosisA549 CellsGasderminsHeLa CellsHumansLipopolysaccharidesAnti-Bacterial AgentsendolysinEndopeptidasesGasderminsGSDMD protein, humanIntracellular Signaling Peptides and ProteinsLipopolysaccharidesPhosphate-Binding Proteinsendolysingasdermin Douter membrane permeabilizationPseudomonas aeruginosa LPSpyroptosis

Identifiers

PMID39714210
PMCPMC11748493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.