Evidence map›Paper›PMID 39714192›Full record

ArticleApplied and environmental microbiology2025

Identification of an antibiotic from an HTS targeting EF-Tu:tRNA interaction: a prospective topical treatment for MRSA skin infections.

Wlodek Mandecki, Maxim Chudaev, Wenjuan Ye, Amy Q Wang, Kenneth J Wilson, Xin Xu, Jisun Kim, Dane Parker, David Alland, Pradeep Kumar and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wlodek MandeckiDepartment of Microbiology, Biochemistry, & Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, USA.ORCID 0009-0002-7150-5885
Maxim ChudaevDepartment of Microbiology, Biochemistry, & Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Wenjuan YeNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Amy Q WangNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Kenneth J WilsonNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Xin XuNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Jisun KimDepartment of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Dane ParkerDepartment of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
David AllandPublic Health Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA.ORCID 0000-0001-5196-1571
Pradeep KumarPublic Health Research Institute, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Barry LiDepartment of Microbiology, Biochemistry & Molecular Genetics, Ruy V. Lourenço Center for Emerging and Re-Emerging Pathogens, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Jason H YangDepartment of Microbiology, Biochemistry & Molecular Genetics, Ruy V. Lourenço Center for Emerging and Re-Emerging Pathogens, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Barry KreiswirthCenter for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.ORCID 0000-0002-0243-131X
Jose R MediavillaCenter for Discovery & Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
Juan J MaruganNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Mark J HendersonNational Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Emanuel GoldmanDepartment of Microbiology, Biochemistry, & Molecular Genetics, Rutgers New Jersey Medical School, Newark, New Jersey, USA.ORCID 0000-0002-6748-0884

Funding

New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Systems Biology CoreU19AI162598 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI DIETZE, REYNALDO · 2021 to 2025
$13.9M
Rutgers Optimizes Innovation (ROI) ProgramU01HL150852 · NHLBI · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI LIBUTTI, STEVEN K., PANETTIERI, REYNOLD ALEXANDER · 2019 to 2022
$4.4M
NCATS NIH HHS UL1 TR003017NHLBI NIH HHS U01 HL150852NIAID NIH HHS U19 AI162598
6 · The paper itself

Abstract

Because of the urgent need for new antibiotics to treat drug-resistant bacterial pathogens, we employed an assay that rapidly screens large quantities of compounds for their ability to interfere with bacterial protein synthesis, in particular, the delivery of amino acids to the ribosome via tRNA and elongation factor Tu (EF-Tu). We have identified a drug lead, named MGC-10, which kills Gram-positive bacteria, including methicillin-resistant

Indexed as

Anti-Bacterial AgentsHigh-Throughput Screening AssaysPeptide Elongation Factor TuRNA, TransferStaphylococcal Skin InfectionsAdministration, TopicalAnimalsChlorocebus aethiopsFemaleFluorescence Resonance Energy TransferMaleMice, Inbred C57BLMicrobial Sensitivity TestsProtein BindingRats, Sprague-DawleyVero CellsAnti-Bacterial AgentsPeptide Elongation Factor TuRNA, TransferFRET(R,R)-tetrahydrochryseneStaphylococcus aureusternary complex in protein synthesistopical antibiotic for Gram-positive pathogens

Identifiers

PMID39714192
PMCPMC11784183

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.