Evidence map›Paper›PMID 39714166›Full record

ArticleJournal of virology2025

Single-chain antibody gene therapy strategy based on high-throughput screening triggers sustained antiviral activity in the body.

Liang Zhao, Xue-Feng Wei, Kun Xu, Zhao Zhao, Guo Chen, Hou-Peng Wang, Bin Zhu

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Liang Zhao *College of Animal Science and Technology, Northwest A&F University College of Animal Science and Technology, Yangling, China.
Xue-Feng Wei *College of Animal Science and Technology, Northwest A&F University College of Animal Science and Technology, Yangling, China.
Kun XuCollege of Animal Science and Technology, Northwest A&F University College of Animal Science and Technology, Yangling, China.ORCID 0000-0001-5714-9090
Zhao Zhao *College of Animal Science and Technology, Northwest A&F University College of Animal Science and Technology, Yangling, China.
Guo Chen *College of Animal Science and Technology, Northwest A&F University College of Animal Science and Technology, Yangling, China.
Hou-Peng WangState Key Laboratory of Freshwater Ecology and Biotechnology, Hongshan Laboratory, Institute of Hydrobiology, Innovation Academy for Seed Design, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0002-7462-6562
Bin ZhuCollege of Animal Science and Technology, Northwest A&F University College of Animal Science and Technology, Yangling, China.ORCID 0000-0001-5702-524X

Funding

MOST | National Natural Science Foundation of China (NSFC) 32173011
6 · The paper itself

Abstract

The occurrence of viral diseases poses a huge threat and impact on human public health safety and the development of the animal and fishery industry. Here, a strain of single-chain antibody fragment, scFv-1, was isolated from the phage antibody display library construct by immunizing New Zealand white rabbits with rhabdovirus.

Indexed as

Antibodies, ViralAntiviral AgentsGenetic TherapySingle-Chain AntibodiesAnimalsAntibodies, NeutralizingHigh-Throughput Screening AssaysHumansImmunization, PassiveRabbitsRhabdoviridaeAntibodies, NeutralizingAntibodies, ViralAntiviral AgentsSingle-Chain Antibodiesantibody gene transferneutralization gene therapysingle-chain antibodiesviral diseases

Identifiers

PMID39714166
PMCPMC11784017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.