Evidence map›Paper›PMID 39714095›Full record

ArticleInfection and immunity2025

Immunometabolic reprogramming in macrophages infected with active and dormant

Clara Luna Marina, Raffael J Araújo de Castro, Paula Bellozi, Ana M Cruz, Pedro Henrique Bürgel, Paul G Weightman Potter, Craig Beall, Aldo Henrique Tavares, Andreza De Bem, Alexandre Alanio and 2 more

Abstract read
In one paragraph

Article in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Molecular remodelling ofJournal of medical microbiology · 2026
    Article
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Clara Luna MarinaLaboratory of Applied Immunology, Institute of Biology Sciences, University of Brasília, Brasília, Brazil.ORCID 0000-0002-0819-0756
Raffael J Araújo de CastroLaboratory of Applied Immunology, Institute of Biology Sciences, University of Brasília, Brasília, Brazil.ORCID 0000-0002-5207-8892
Paula BelloziLaboratory of Bioenergetics and Metabolism, Institute of Biology Sciences, University of Brasília, Brasília, Brazil.
Ana M CruzFaculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Pedro Henrique BürgelLaboratory of Applied Immunology, Institute of Biology Sciences, University of Brasília, Brasília, Brazil.ORCID 0000-0002-7690-2997
Paul G Weightman PotterFaculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Craig BeallFaculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.
Aldo Henrique TavaresGraduate Program in Microbial Biology, Department of Cell Biology, Institute of Biological Sciences, Laboratory of Microorganism, Faculty of Ceilândia, University of Brasília, Brasília, Brazil.
Andreza De BemLaboratory of Bioenergetics and Metabolism, Institute of Biology Sciences, University of Brasília, Brasília, Brazil.
Alexandre AlanioTranslational Mycology Research Group, National Reference Center for Invasive Mycoses and Antifungals, Mycology Department, Institut Pasteur, Université Paris Cité, Paris, Île-de-France, France.ORCID 0000-0001-9726-3082
Carolina Coelho *Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom.ORCID 0000-0002-7523-3031
Anamélia Lorenzetti Bocca *Laboratory of Applied Immunology, Institute of Biology Sciences, University of Brasília, Brasília, Brazil.ORCID 0000-0003-3323-5300

Funding

Rapid production of SARS-CoV-2 molecular clones using CRISPR-based yeast recombineeringR01AI100272 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MADHANI, HITEN D · 2012 to 2025
$11.3M
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) 305584/2023-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 88887.569579/2020-00,88881.364618/2019-01Medical Research Council MR/V033417/1Medical Research Council Centre for Medical Mycology (MRC CMM) MR/N006364/2,MR/V033417/1NIAID NIH HHS R01 AI100272Springboard Foundation (The Springboard Foundation) SBF006/1024University of Exeter 1-INO-2020-919-A-N,3-PDF-2020-941-A-NWellcome TrustWellcome Trust (WT) WT105618MA
6 · The paper itself

Abstract

Dormancy is an adaptation in which cells reduce their metabolism, transcription, and translation to stay alive under stressful conditions, preserving the capacity to reactivate once the environment reverts to favorable conditions. Dormancy and reactivation of

Indexed as

CryptococcosisCryptococcus neoformansFatty AcidsGlycolysisMacrophagesAnimalsMembrane Potential, MitochondrialMiceMice, Inbred C57BLMitochondriaOxygen ConsumptionFatty AcidsAcod1Cryptococcus neoformansdormancyFabp1Fabp4immunometabolismmacrophageVBNC

Identifiers

PMID39714095
PMCPMC11834436

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.