ArticleJournal of clinical laboratory analysis2025
Comparative Prognostic Value of Glomerular Filtration Rate, Serum Cystatin C, Beta-2-Microglobulin and Albuminuria for Death and Chronic Kidney Disease Progression.
Article in Journal of clinical laboratory analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy.PLoS genetics · 2026Article
- Bridging conventional clinical tests and advanced biomarkers for the early diagnosis of kidney disease progression.Pakistan journal of medical sciences · 2025Article
- Cystatin C for gentamicin dosing - a case study.Biochemia medica · 2025Article
- Incidence of new-onset HFpEF across CKD stages and Its association with cardio-renal, inflammatory, and fibrotic biomarkers.Frontiers in cardiovascular medicine · 2025Article
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9 authors.
Funding
Abstract
aimsSerum creatinine and albuminuria are the core of most CKD prediction and progression risk models. Several biomarkers have been introduced to improve these results such as beta-2-microglobulin (B2M) and cystatin C (CysC). Nevertheless, few clinical comparisons of these biomarkers are available. We have compared serum B2M levels with albuminuria, CysC levels, and the CKD-EPI GFR equations. DESIGNS AND
methodsA sample of 434 patients were studied: 234 males and 200 females, the mean age was 58.3 ± 15.0 years, and 33.4% have diabetes mellitus. In all patients, plasma B2M, CysC, creatinine, and urinary albumin excretion were analyzed. EGFR was calculated using CKD-EPI equations for creatinine, CysC, and creatinine-CysC. The risk of death and CKD progression was evaluated using ROC curves and Cox proportional hazards survivorship models.
resultsFor mortality, the highest area under the curve (AUC) was for CysC (0.775, 0.676-0.875). The lowest sensitivity was shown by eGFR (creatinine) (0.298, 0.195-0.401, p < 0.001), eGFR (CysC) (0.216, 0.118-0.314, p < 0.001), and eGFR (creatinine + CysS) (0.218, 0.124-0.312, p < 0.001). For progression to advanced CKD, the highest AUC was for CysC (0.908, 0.862-0.954). The lowest sensitivity was shown by eGFR (creatinine) (0.184, 0.106-0.261, p < 0.001), eGFR (CysC) (0.095, 0.048-0.14, p < 0.001), and eGFR (creatinine+ CysC) (0.087, 0.040-0.134, p < 0.001). CysC, after age, was the second-best marker of life risk. Contrariwise, for CKD progression, CysC, and albuminuria were the best markers.
conclusionsThe best biomarker of mortality and risk of progression to CKD was CysC. Albuminuria and B2M were the next best options to be used. The lowest sensitivity was shown by estimated eGFR.
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