ArticleCNS neuroscience & therapeutics2024
The Effect of Alcohol Consumption on Progressive Supranuclear Palsy: A Cross-Sectional Study.
Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain connectivity changes associated with acute sleep deprivation: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- CAR T-cell immunotherapy as the next horizon in cancer eradication: current landscape, challenges, and future directions.Medical oncology (Northwood, London, England) · 2025Review
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Authors and funding
10 authors.
Funding
Abstract
aimsTo investigate the effect of alcohol consumption on the clinical symptoms in a cohort of Progressive supranuclear palsy (PSP) patients.
methodsWe conducted a cross-sectional study focusing on possible and probable PSP patients in Qilu Hospital of Shandong University. Diagnoses and clinical phenotypes were confirmed using the 2017 Movement Disorder Society criteria and the Multiple Allocations eXtinction (MAX) rules. Data on drinking habits and demographics were collected via face-to-face interviews and medical records reviews. Clinical scales assessed motor and nonmotor symptoms. Alcohol consumption was categorized into light, moderate, and heavy status. Using multivariate linear regression and adjusting for confounding factors, we analyzed the relationship between alcohol consumption and clinical symptoms.
resultsThe study comprised 128 participants (59.4% male and 45.31% drinkers). Alcohol consumption has been associated with severe PSP clinical symptoms, particularly among male patients. Compared with nondrinkers, consumers of alcohol exhibit significantly more severe motor symptoms and cognitive impairments, particularly in the domains of visuospatial and executive abilities, memory, and language. Moreover, when categorizing individuals based on their intake of alcohol weekly, those with heavy consumption show significantly higher PSP Rating Scale (PSPRS) and the Unified Parkinson's Disease Rating Scale (UPDRS) scores, as well as significantly lower Montreal Cognitive Assessment Scale (MoCA) and Mini Mental State Examination (MMSE) scores compared to nonconsumers.
conclusionOur findings indicate an association between heavy alcohol consumption and more pronounced symptoms of PSP, especially cognitive function. It raises the possibility that alcohol intake may play a role in modulating the clinical course of PSP.
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