Evidence map›Paper›PMID 39713898›Full record

ArticleAdvanced healthcare materials2025

Structured Polymers Enable the Sustained Delivery of Glucocorticoids within the Intra-Articular Space.

Ana Crastin, Claire S Martin, Sai Suresh, Scott P Davies, Daniel Kearns, Ahsen Parlak, Holly Adcock, Andrew Filer, Simon W Jones, Karim Raza and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ana CrastinDept of Biomedical Sciences. Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
Claire S MartinDept of Metabolism and Systems Science, University of Birmingham, Birmingham, UK.
Sai SureshDept of Biomedical Sciences. Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
Scott P DaviesCentre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Daniel KearnsCentre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Ahsen ParlakDept of Biomedical Sciences. Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.
Holly AdcockSchool of Chemistry, University of Birmingham, Birmingham, UK.
Andrew FilerDept of Inflammation and Aging, University of Birmingham, Birmingham, UK.
Simon W JonesMRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK.
Karim RazaDept of Inflammation and Aging, University of Birmingham, Birmingham, UK.
Richard Ja MoakesHealthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, UK.
Liam M GroverHealthcare Technologies Institute, School of Chemical Engineering, University of Birmingham, Birmingham, UK.
Rowan S HardyDept of Biomedical Sciences. Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.ORCID 0000-0001-6938-6739

Funding

Medical Research Council MC_PC_19029Versus Arthritis 20843Wellcome TrustWellcome Trust 215243/Z/19/Z
6 · The paper itself

Abstract

Intra-articular glucocorticoid injections are effective in controlling inflammation and pain in arthritides but restricted by short duration of action and risk of joint degeneration. Controlled drug release using biocompatible hydrogels offers a unique solution, but limitations of in situ gelation restrict their application. Gellan sheared hydrogels (GSHs) retain the advantages of hydrogels, however their unique microstructures lend themselves to intra-articular application - capable of shear thinning under force but restructuring at rest to enhance residence. This study examined GSHs for extended intra-articular glucocorticoid delivery of prednisolone (10 mg mL

Indexed as

Drug Delivery SystemsGlucocorticoidsPolymersAnimalsDelayed-Action PreparationsHydrogelsInjections, Intra-ArticularMiceMice, TransgenicPolysaccharides, BacterialPrednisoloneDelayed-Action PreparationsGlucocorticoidsHydrogelsPolymersPolysaccharides, BacterialPrednisolonearthritisgellanglucocorticoidintra‐articularsheared hydrogel

Identifiers

PMID39713898
PMCPMC11804841

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.