Evidence map›Paper›PMID 39713897›Full record

ReviewJournal of clinical research in pediatric endocrinology2025

Central Adrenal Insufficiency: Etiology and Diagnostic Approach

Melek Yıldız, Ruken Yıldırım, Firdevs Baş

Abstract readReview
In one paragraph

Review in Journal of clinical research in pediatric endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. An overview of hypopituitarism's causes.Frontiers in endocrinology · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Melek Yıldızİstanbul University, İstanbul Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, TurkeyORCID 0000-0002-6603-2983
Ruken YıldırımDiyarbakır Children’s Hospital, Clinic of Pediatrics, Diyarbakır, TurkeyORCID 0000-0002-9558-3856
Firdevs Başİstanbul University, İstanbul Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, TurkeyORCID 0000-0001-9689-4464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central adrenal insufficiency (CAI) occurs due to a pituitary gland disorder (secondary AI) or hypothalamic dysfunction (tertiary AI). It is a potentially life-threatening condition that has many congenital and acquired causes. Adrenocorticotropic hormone deficiency may be isolated or more commonly it can be accompanied by other pituitary hormone deficiencies or midline defects. The signs and symptoms of CAI are associated with glucocorticoid deficiency. A three-step diagnostic approach including dynamic stimulation tests is recommended in the evaluation of patients with suspected CAI. Here, members of the ‘Adrenal Working Group’ of ‘The Turkish Society for Pediatric Endocrinology and Diabetes’ present an evidence-based review with good practice points and recommendations for etiology and diagnostic approach in children and adolescents with CAI.

Indexed as

Adrenal InsufficiencyAdolescentAdrenocorticotropic HormoneChildHumansAdrenocorticotropic HormoneACTHCentral adrenal insufficiencychildrenguidelinesecondary

Identifiers

PMID39713897
PMCPMC11730094

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.