Evidence map›Paper›PMID 39713813›Full record

ArticleAnalytical chemistry2025

Millisecond Label-Free Single Peptide Detection and Identification Using Nanoscale Electrochromatography and Resistive Pulse Sensing.

Maximillian Chibuike, Chathurika Rathnayaka, Suresh Shivanka, Junseo Choi, Matthew Verber, Sunggook Park, Steven A Soper

Abstract read
In one paragraph

Article in Analytical chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maximillian ChibuikeDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Chathurika RathnayakaDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Suresh ShivankaDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.
Junseo ChoiDepartment of Engineering Technology, Texas State University, San Marcos, Texas 78666, United States.ORCID 0000-0002-3461-3820
Matthew VerberDepartment of Chemistry, University of North Carolina, Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Sunggook ParkCenter of Biomodular Multiscale Systems for Precision Medicine, The University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0003-0424-6318
Steven A SoperDepartment of Chemistry, The University of Kansas, Lawrence, Kansas 66045, United States.ORCID 0000-0002-8292-7058

Funding

Understanding the mechanobiology of stem cells in a microengineered 3D cardiac tissue environment with cardiomyopathyP20GM103638 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI LUNTE, SUSAN M · 2012 to 2021
$22.1M
Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
Single-Molecule Processing: Detection and Identification of Single DNAs, RNAs, and Proteins using Immobilized Nanoscale Enzymatic Reactors (INERs) and Nanoscale ElectrophoresisP41EB020594 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Adam Roger Hall · 2015 to 2026
$15.2M
Synthetic Chemical Biology CoreP30GM145499 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI Susan M Lunte · 2022 to 2026
$6.9M
mRNA Expression Profiling from Extracellular Vesicles (EVs): Generating a Rapid Diagnostic for StrokeR01EB031579 · NIBIB · UNIVERSITY OF KANSAS LAWRENCE · PI BAIRD, ALISON E, SOPER, STEVEN ALLAN · 2022 to 2025
$2.3M
Increased Sensitivity of Minimal Residual Disease Monitoring using Peripheral Blood in Pediatric Patients with Acute Lymphoblastic LeukemiaR33CA235597 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI AUGUST, KEITH, SOPER, STEVEN ALLAN · 2019 to 2022
$906k
Molecular Sub-typing Breast Cancer Patients using a Liquid BiopsyR21CA272351 · NCI · UNIVERSITY OF KANSAS LAWRENCE · PI SOPER, STEVEN ALLAN · 2022 to 2024
$558k
NCI NIH HHS R21 CA272351NCI NIH HHS R33 CA235597NIBIB NIH HHS P41 EB020594NIBIB NIH HHS R01 EB031579NIGMS NIH HHS P20 GM103638NIGMS NIH HHS P20 GM130423NIGMS NIH HHS P30 GM145499
6 · The paper itself

Abstract

We are developing a unique protein identification method that consists of generating peptides proteolytically from a single protein molecule (i.e., peptide fingerprints) with peptide detection and identification carried out using nanoscale electrochromatography and label-free resistive pulse sensing (RPS). As a step in realizing this technology, we report herein the nanoscale electrochromatography of model peptides using thermoplastic columns with surfaces engineered to identify peptides via their molecularly dependent mobility (i.e., time-of-flight, ToF). ToFs were elucidated using a dual in-plane nanopore sensor, which consisted of two in-plane nanopores placed on either end of the nanoelectrochromatography column. The surface of the nanocolumn, which consisted of poly(methyl methacrylate) (PMMA), was activated with an O

Indexed as

Capillary ElectrochromatographyNanotechnologyPeptidesNanoporesPolymethyl MethacrylatePeptidesPolymethyl Methacrylate

Identifiers

PMID39713813
PMCPMC12006914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.