ArticleJournal of inflammation research2024
Age-Related Association Between Circulating Inflammatory Indicators and Plaque Enhancement on High-Resolution Magnetic Resonance Imaging in Patients with Intracranial Atherosclerotic Stenosis.
Article in Journal of inflammation research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Atherosclerotic plaque distribution and characteristics in young patients with stroke/transient ischemic attack: insights from MR vessel wall imaging and comparison with older counterparts.Quantitative imaging in medicine and surgery · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Plaque enhancement is a non-specific marker of local inflammatory response, which may offer additional insights together with circulating inflammatory markers. Few studies have analyzed the association between intracranial atherosclerotic stenosis (ICAS) plaque enhancement and circulating inflammatory markers. Given the age-related variability in the progression of ICAS, this study aims to explore the association between the two across different age groups. Methods: This retrospective study recruited 120 patients with ICAS-related ischemic events who had undergone high-resolution magnetic resonance imaging. Plaque enhancement index at the most stenosed site of the culprit vessel was calculated. Levels of circulating inflammatory indicators, including high-sensitivity C-reactive protein (hsCRP), lymphocyte-to-white blood cell ratio (LWR), systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and neutrophil-to-lymphocyte ratio (NLR), were detected. General linear regression models were established to analyze the association between ICAS plaque enhancement index and circulating inflammatory indicators. Results: In this study, hsCRP, but not other circulating inflammatory indicators, had a significant positive association with ICAS plaque enhancement index (β=0.219, 95% CI [0.036, 0.349], Conclusion: ICAS plaque enhancement index was positively associated with hsCRP, particularly in participants aged <60 years. This may be helpful for understanding the significance of the enhancement index in clinical practice.
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