ArticleACS omega2024
Rolling Circle Amplification Integrating with Exonuclease-III-Assisted Color Reaction for Sensitive Telomerase Activity Analysis.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Split G‑Quadruplex-Programmed Fluorescent Platform for Low Background Signal and Sensitive Nonsmall Cell Lung Cancer-Related MicroRNA Analysis.ACS omega · 2026Article
- λ-exonuclease-driven split G-quadruplex hybridization-based DNA walking system for sensitive microRNA quantification.Biotechnology letters · 2025Article
- Single-Step Detection of microRNA via the Programmable DNAzyme Probe-Mediated Multiple Signal Recycling.ACS omega · 2025Article
- Exonuclease-III Assisted Signal Cycle Integrating with Self-Priming Mediated Chain Extension for Sensitive and Reliable MicroRNA Detection.ACS omega · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
Telomerase activation can lead to the escape from cell senescence and immortalization, playing a crucial role in the growth and proliferation of cancer cells. Therefore, the detection of telomerase activity is essential for cancer diagnosis and treatment. Herein, we develop a novel ultrasensitive and visually detectable platform. By incorporation of exonuclease-III (Exo-III), this platform achieves dual signal amplification of rolling circle amplification products. Additionally, the colorimetric analysis of 3,3',5,5'-tetramethylbiphenyl (TMB) chromogenic reaction system provides this approach with unique advantages such as simplicity, speediness, and sensitivity. The detection platform exhibits high sensitivity and specificity in actual sample testing, which aligns closely with results obtained using commercial kits. Moreover, it offers ease-of-use through visual determination by the naked eyes. This finding indicates that our proposed sensing method performs satisfactorily in detecting telomerase in real biological samples. Henceforth, we believe that this sensing platform holds great potential for clinical diagnosis and anticancer drug development.
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Registered trials
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