Evidence map›Paper›PMID 39713463›Full record

ArticlebioRxiv : the preprint server for biology2024

Antibodies disrupt bacterial adhesion by ligand mimicry and allosteric interference.

Kelli L Hvorecny, Gianluca Interlandi, Tim S Veth, Pavel Aprikian, Anna Manchenko, Veronika L Tchesnokova, Miles S Dickinson, Joel D Quispe, Nicholas M Riley, Rachel E Klevit and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kelli L HvorecnyDepartment of Biochemistry, University of Washington, Seattle, WA.
Gianluca InterlandiDepartment of Bioengineering, University of Washington, Seattle, WA.
Tim S VethDepartment of Chemistry, University of Washington, Seattle, WA.
Pavel AprikianDepartment of Microbiology, University of Washington, Seattle, WA.
Anna ManchenkoDepartment of Microbiology, University of Washington, Seattle, WA.
Veronika L TchesnokovaDepartment of Microbiology, University of Washington, Seattle, WA.ORCID 0000-0002-4235-5796
Miles S DickinsonDepartment of Biochemistry, University of Washington, Seattle, WA.
Joel D QuispeDepartment of Biochemistry, University of Washington, Seattle, WA.
Nicholas M RileyDepartment of Chemistry, University of Washington, Seattle, WA.
Rachel E KlevitDepartment of Biochemistry, University of Washington, Seattle, WA.ORCID 0000-0002-3476-969X
Pearl MagalaDepartment of Biochemistry, University of Washington, Seattle, WA.
Evgeni V SokurenkoDepartment of Microbiology, University of Washington, Seattle, WA.
Justin M KollmanDepartment of Biochemistry, University of Washington, Seattle, WA.

Funding

Allosteric adhesins of enterobacterial pathogensR01AI171570 · NIAID · UNIVERSITY OF WASHINGTON · PI Rachel E Klevit, EVGENI Veniaminovic SOKURENKO · 2022 to 2026
$3.5M
Structure and function of metabolic enzyme assembliesR35GM149542 · NIGMS · UNIVERSITY OF WASHINGTON · PI Justin M Kollman · 2023 to 2026
$2.2M
Acquisition of a high resolution, high throughput cryo-electron microscopeS10OD023476 · OD · UNIVERSITY OF WASHINGTON · PI KOLLMAN, JUSTIN M · 2017 to 2017
$2.0M
Capturing the Holistic Glycocode through Systems GlycobiologyR00GM147304 · NIGMS · UNIVERSITY OF WASHINGTON · PI Nicholas M Riley · 2024 to 2026
$747k
Investigating Novel Methods to Combat Urinary Tract InfectionsK99GM141364 · NIGMS · UNIVERSITY OF WASHINGTON · PI MAGALA, PEARL · 2022 to 2023
$225k
Structurally and biochemically defining divergent actin and its non-canonical regulators in GiardiaF32AI145111 · NIAID · UNIVERSITY OF WASHINGTON · PI HVORECNY, KELLI L. · 2020 to 2022
$206k
NIAID NIH HHS F32 AI145111NIAID NIH HHS R01 AI171570NIGMS NIH HHS K99 GM141364NIGMS NIH HHS R00 GM147304NIGMS NIH HHS R35 GM149542NIH HHS S10 OD023476
6 · The paper itself

Abstract

A critical step in infections is the attachment of many microorganisms to host cells using lectins that bind surface glycans, making lectins promising antimicrobial targets. Upon binding mannosylated glycans, FimH, the most studied lectin adhesin of type 1 fimbriae in

Identifiers

PMID39713463
PMCPMC11661100

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.