In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
11 authors.
Katherine M StefanskiDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-3007-0598 Hui HuangDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-2958-257X Dustin D LuuSchool of Molecular Sciences; The Virginia G. Piper Biodesign Center for Personalized Diagnostics, Arizona State University, Tempe, AZ, USA.ORCID 0000-0003-3464-160X James M HutchisonDepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA; Yale Cancer Biology Institute, Yale University West Campus, West Haven, CT, USA.ORCID 0000-0002-5529-3248 Nilabh SaksenaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0009-0001-9374-5006 Alexander J FischDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-4741-7084 Thomas P HasakaDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Joshua A BauerDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0002-8019-900X Anne K KenworthyCenter for Membrane and Cell Physiology and Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA.ORCID 0000-0001-6567-9059 Wade D Van HornSchool of Molecular Sciences; The Virginia G. Piper Biodesign Center for Personalized Diagnostics, Arizona State University, Tempe, AZ, USA.ORCID 0000-0002-2493-5578 Charles R SandersDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.ORCID 0000-0003-2046-2862 Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Marcela Brissova · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MVanderbilt Mouse Metabolic Physiology CenterU24DK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2001 to 2015
$14.9MFolding, Misfolding, and Function of PMP22R01NS095989 · NINDS · VANDERBILT UNIVERSITY · PI Bruce D Carter, CHARLES R SANDERS · 2016 to 2026
$4.6MMolecular Mechanisms and Regulation Networks of TRPM8 - Renewal - 1R35GM141933 · NIGMS · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · PI Wade D. Van Horn · 2021 to 2026
$2.5MCancer Pharmacologist and HTS ScientistR50CA211206 · NCI · VANDERBILT UNIVERSITY · PI Joshua A. Bauer · 2016 to 2026
$1.8MSmall Molecule Tools for Modulating Membrane RaftsR01GM138493 · NIGMS · UNIVERSITY OF VIRGINIA · PI KENWORTHY, ANNE K, SANDERS, CHARLES R · 2020 to 2022
$1.2MIntegrated ImageXpress Micro Confocal High Content Screening SystemS10OD028719 · OD · VANDERBILT UNIVERSITY · PI BAUER, JOSHUA A. · 2021 to 2021
$799kAutomated Compound Storage and Retrieval SystemS10OD028715 · OD · VANDERBILT UNIVERSITY · PI BAUER, JOSHUA A. · 2022 to 2022
$741kLSM880-Airyscan Confocal Microscope for Large Shared ResourceS10OD021630 · OD · VANDERBILT UNIVERSITY · PI WELLS, K. SAM · 2016 to 2016
$560kNCATS NIH HHS R13 TR000044NCATS NIH HHS U13 TR000044NCI NIH HHS P30 CA068485NCI NIH HHS R50 CA211206NEI NIH HHS P30 EY008126NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS U24 DK059637NIGMS NIH HHS F32 GM151766NIGMS NIH HHS R01 GM138493NIGMS NIH HHS R35 GM141933NIH HHS S10 OD021630NIH HHS S10 OD028715NIH HHS S10 OD028719NINDS NIH HHS R01 NS095989
6 · The paper itselfAbstract
Development of an understanding of membrane nanodomains colloquially known as "lipid rafts" has been hindered by a lack of pharmacological tools to manipulate rafts and protein affinity for rafts. We screened 24,000 small molecules for modulators of the affinity of peripheral myelin protein 22 (PMP22) for rafts in giant plasma membrane vesicles (GPMVs). Hits were counter-screened against another raft protein, MAL, and tested for impact on raft , leading to two classes of compounds. Class I molecules altered the raft affinity of PMP22 and MAL and also reduced raft formation in a protein-dependent manner. Class II molecules modulated raft formation in a protein-independent manner. This suggests independent forces work collectively to stabilize lipid rafts. Both classes of compounds altered membrane fluidity in cells and modulated TRPM8 channel function. These compounds provide new tools for probing lipid raft function in cells and for furthering our understanding of raft biophysics.
Identifiers
PMID39713458
PMCPMC11661060
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