In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
20 authors.
Sandhya BangaruDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0001-7994-4693 Abigail M JacksonDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0001-9749-9431 Jeffrey CoppsDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0003-4793-7258 Monica L Fernández-QuinteroDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.
Jonathan L TorresDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0003-0137-8497 Sara T RicheyDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0001-7854-1833 Bartek NogalDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0001-8977-7470 Leigh M SewallDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0002-2020-2991 Alba Torrents de la PeñaDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0001-5598-1780 Mimi Guebre-XabierNovavax, Inc; 21 Firstfield Road, Gaithersburg, MD, 20878, USA.
Rituparna DasModerna, Inc; Cambridge, MA, 02142, USA.
Kizzmekia S Corbett-HelaireVaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892, USA.ORCID 0000-0002-2641-4688 Robert A SederVaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892, USA.
Barney S GrahamVaccine Research Center; National Institutes of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, Maryland, 20892, USA.ORCID 0000-0001-8112-0853 Nita PatelNovavax, Inc; 21 Firstfield Road, Gaithersburg, MD, 20878, USA.
Andrew B WardDept. of Integrative Structural and Computational Biology, The Scripps Research Institute; La Jolla, CA, 92037, USA.ORCID 0000-0001-7153-3769 Funding
Identification of neutralizing epitopes on SARS-CoV-2 spike for design of vaccines and small-molecule antiviralsUM1AI144462 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI BURTON, DENNIS R. · 2019 to 2025
$201.6MPacific Northwest Center for Cryo-EM: Equipment SupplementR24GM154185 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Evans, CLAUDIA SUSANA LOPEZ · 2024 to 2026
$21.5MXRAY CRYSTALLOGRAPHIC STRUCTURE ANALYSIS: PROTEIN SORTINGP41RR001081 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1985 to 2011
$17.6MStructure, Function and Antigenicity of Coronavirus Spike ProteinsR01AI127521 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MCLELLAN, JASON SCOTT, WARD, ANDREW BARRETT · 2017 to 2021
$3.1MGates Foundation INV-004923NCRR NIH HHS P41 RR001081NIAID NIH HHS R01 AI127521NIAID NIH HHS UM1 AI144462NIGMS NIH HHS R24 GM154185
6 · The paper itselfAbstract
Current COVID-19 vaccines are largely limited in their ability to induce broad, durable immunity against emerging viral variants. Design and development of improved vaccines utilizing existing platforms requires an in-depth understanding of the antigenic and immunogenic properties of available vaccines. Here we examined the antigenicity of two of the original COVID-19 vaccines, mRNA-1273 and NVX-CoV2373, by electron microscopy-based polyclonal epitope mapping (EMPEM) of serum from immunized non-human primates (NHPs) and clinical trial donors. Both vaccines induce diverse polyclonal antibody (pAb) responses to the N-terminal domain (NTD) in addition to the receptor-binding domain (RBD) of the Spike protein, with the NTD supersite being an immunodominant epitope. High-resolution cryo-EMPEM studies revealed extensive pAb responses to and around the supersite with unique angles of approach and engagement. NTD supersite pAbs were also the most susceptible to variant mutations compared to other specificities, indicating that ongoing Spike ectodomain-based vaccine design strategies should consider immuno-masking this site to prevent induction of these strain-specific responses.
Identifiers
PMID39713412
PMCPMC11661243
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