Evidence map›Paper›PMID 39713411›Full record

ArticlebioRxiv : the preprint server for biology2025

BioMedGraphica: An All-in-One Platform for Joint Textual Biomedical Prior Knowledge and Numeric Graph Generation.

Heming Zhang, Shunning Liang, Tim Xu, Wenyu Li, Di Huang, Yuhan Dong, Guangfu Li, J Philip Miller, S Peter Goedegebuure, Marco Sardiello and 9 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Heming ZhangThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-2025-9090
Shunning LiangThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.
Tim XuThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.
Wenyu LiDepartment of Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Di HuangThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.
Yuhan DongThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.
Guangfu LiDepartment of Surgery, School of Medicine, University of Connecticut, CT, 06032, USA.
J Philip MillerThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.
S Peter GoedegebuureDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Marco SardielloDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Jonathan CooperDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1339-4750
William BuchserDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Patricia DicksonDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Ryan C FieldsDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, USA.
Carlos CruchagaDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0276-2899
Yixin ChenDepartment of Computer Science and Engineering, Washington University in St. Louis, St. Louis, MO, USA.
Michael ProvinceDivision of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
Philip PayneThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-9532-2998
Fuhai LiThe Center for Translational Bioinformatics (CTBI), Institute for Informatics, Data Science and Biostatistics (I2DB), Washington University School of Medicine, St. Louis, MO, USA.

Funding

Systems-Level Approach to Neuronopathic Lysosomal Storage DisordersRM1NS132962 · NINDS · WASHINGTON UNIVERSITY · PI JONATHAN D COOPER, PATRICIA I DICKSON · 2023 to 2026
$6.3M
Modeling and targeting tumor-immune signaling interactions in tumor microenvironmentR01LM013902 · NLM · WASHINGTON UNIVERSITY · PI Fuhai Li · 2023 to 2026
$1.4M
Combine Genomics and Symptoms Data Driven Models to Discover Synergistic Combinatory Therapies for Alzheimer's DiseaseR56AG065352 · NIA · WASHINGTON UNIVERSITY · PI LI, FUHAI · 2020 to 2021
$986k
AI models of multi-omic data integration for ming longevity core signaling pathwaysR21AG078799 · NIA · WASHINGTON UNIVERSITY · PI LI, FUHAI, PROVINCE, MICHAEL A. · 2023 to 2023
$461k
NIA NIH HHS R21 AG078799NIA NIH HHS R56 AG065352NINDS NIH HHS RM1 NS132962NLM NIH HHS R01 LM013902
6 · The paper itself

Abstract

Multi-omic data analysis is essential for scientific discovery in precision medicine. However, translating statistical results of omic data analysis into novel scientific hypothesis remains a significant challenge. Human experts must manually review analysis results and generate new hypothesis based on extensive and inter-connected biomedical prior knowledge, which is subjective and not scalable. While large language models (LLMs) can accelerate the discovery, their reasoning improves when grounded in structured, auditable and comprehensive biomedical prior knowledge. Biomedical knowledge, however, is scattered across heterogeneous databases that use diverse and inconsistent nomenclature systems, making it difficult to integrate resources into a unified format for scalable analysis. This fragmentation limits the ability of AI systems to fully leverage biomedical data for scientific discovery. To address these challenges, we developed

Indexed as

biomedical knowledge graphknowledge graph integration and generationtextual-numeric graph

Identifiers

PMID39713411
PMCPMC11661111

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.