Evidence map›Paper›PMID 39713397›Full record

ArticlebioRxiv : the preprint server for biology2024

Mitochondrial DNA mutations in human oocytes undergo frequency-dependent selection but do not increase with age.

Barbara Arbeithuber, Kate Anthony, Bonnie Higgins, Peter Oppelt, Omar Shebl, Irene Tiemann-Boege, Francesca Chiaromonte, Thomas Ebner, Kateryna D Makova

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Barbara ArbeithuberDepartment of Gynaecology, Obstetrics and Gynaecological Endocrinology, Experimental Gynaecology and Obstetrics, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria.ORCID 0000-0001-8367-1560
Kate AnthonyDepartment of Biology, Penn State University, University Park, PA 16802, USA.
Bonnie HigginsDepartment of Biology, Penn State University, University Park, PA 16802, USA.
Peter OppeltDepartment of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Kepler University Hospital, Altenberger Strasse 69, 4040 Linz and Krankenhausstrasse 26, 4020, Linz, Austria.
Omar SheblDepartment of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Kepler University Hospital, Altenberger Strasse 69, 4040 Linz and Krankenhausstrasse 26, 4020, Linz, Austria.
Irene Tiemann-BoegeInstitute of Biophysics, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria.
Francesca ChiaromonteCenter for Medical Genomics, Penn State University, University Park, PA 16802, USA.
Thomas EbnerDepartment of Gynaecology, Obstetrics and Gynaecological Endocrinology, Johannes Kepler University Linz, Kepler University Hospital, Altenberger Strasse 69, 4040 Linz and Krankenhausstrasse 26, 4020, Linz, Austria.
Kateryna D MakovaDepartment of Biology, Penn State University, University Park, PA 16802, USA.

Funding

The Dynamics of Mitochondrial MutationsR01GM116044 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI MAKOVA, KATERYNA, NIELSEN, RASMUS · 2015 to 2018
$2.4M
NIGMS NIH HHS R01 GM116044
6 · The paper itself

Abstract

Mitochondria, cellular powerhouses, harbor DNA (mtDNA) inherited from the mothers. MtDNA mutations can cause diseases, yet whether they increase with age in human germline cells-oocytes-remains understudied. Here, using highly accurate duplex sequencing of full-length mtDNA, we detected

Identifiers

PMID39713397
PMCPMC11661235

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.