Evidence map›Paper›PMID 39713366›Full record

ArticlebioRxiv : the preprint server for biology2024

An endogenous cluster of target-directed microRNA degradation sites induces decay of distinct microRNA families.

Nicholas M Hiers, Lu Li, Tianqi Li, Peike Sheng, Yuzhi Wang, Conner M Traugot, Michael Yao, Mingyi Xie

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Nicholas M HiersDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0003-0996-364X
Lu LiDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.
Tianqi LiDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.
Peike ShengDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.
Yuzhi WangDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.
Conner M TraugotDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.
Michael YaoDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.
Mingyi XieDepartment of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL, 32610, USA.ORCID 0000-0001-7955-197X

Funding

BASIC MICROBIOLOGY &INFECTIOUS DISEASEST32AI007110 · NIAID · UNIVERSITY OF FLORIDA · PI Stephanie M Karst · 1985 to 2026
$4.3M
RNA metabolism mediated by the Integrator complexR35GM128753 · NIGMS · UNIVERSITY OF FLORIDA · PI MINGYI XIE · 2018 to 2026
$4.0M
Exploring microRNA degradation in T-cell acute lymphoblastic leukemiaR01CA282812 · NCI · UNIVERSITY OF FLORIDA · PI Jonathan D. Licht, MINGYI XIE · 2023 to 2026
$2.1M
NCI NIH HHS R01 CA282812NIAID NIH HHS T32 AI007110NIGMS NIH HHS R35 GM128753
6 · The paper itself

Abstract

While much is known about miRNA biogenesis and canonical miRNA targeting, relatively less is understood about miRNA decay. The major miRNA decay pathway in metazoans is mediated through target-directed miRNA degradation (TDMD), in which certain RNAs can "trigger" miRNA decay. All known triggers for TDMD base pair with the miRNA seed, and extensively base pair on the miRNA 3' end, a pattern that supposedly induces a TDMD-competent conformational change of Argonaute (Ago), allowing for miRNA turnover. Here, we utilized Ago1-CLASH to find that the

Indexed as

AGO-CLASHmicroRNASHAPETDMD

Identifiers

PMID39713366
PMCPMC11661237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.