Evidence map›Paper›PMID 39713358›Full record

ArticlebioRxiv : the preprint server for biology2024

Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic

Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza Sayed Ahmed and 7 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Edward D B LopattoDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.ORCID 0000-0002-6625-6143
Jesús M Santiago-BorgesDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Denise A SanickDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Sameer Kumar MalladiDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, U.S.A.
Philippe N AzimzadehDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Morgan W TimmDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Isabella F FoxDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, U.S.A.
Aaron J SchmitzDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, U.S.A.
Jackson S TurnerDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, U.S.A.
Shaza Sayed AhmedDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, U.S.A.
Lillian OrtinauDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Nathaniel C GualbertoDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Jerome S PinknerDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Karen W DodsonDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.
Ali H EllebedyDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.ORCID 0000-0002-6129-2532
Andrew L KauDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.ORCID 0000-0002-9386-3766
Scott J HultgrenDepartment of Molecular Microbiology, Washington University in St Louis, St Louis, MO, U.S.A.ORCID 0000-0001-8785-564X

Funding

WU P&FP30DK020579 · NIDDK · WASHINGTON UNIVERSITY · PI Clay F. Semenkovich · 2013 to 2026
$27.1M
TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
Rational design and synthesis of small molecule inhibitors targeting unique pathogenic mechanisms in Gram- and Gram+ bacteria important in UTIU19AI157797 · NIAID · WASHINGTON UNIVERSITY · PI ELLEBEDY, ALI HASSAN · 2021 to 2025
$11.4M
CHAPERONE-ASSISTED PILI ASSEMBLY IN PATHOGENIC E. COLIR01AI029549 · NIAID · WASHINGTON UNIVERSITY · PI HULTGREN, SCOTT J., YUAN, PENG · 1991 to 2023
$5.7M
Harnessing Antibody Responses to Prevent and Treat Urinary Tract InfectionsR01AI165915 · NIAID · WASHINGTON UNIVERSITY · PI Andrew Leon Kau · 2022 to 2026
$3.1M
Pathogenic Fiber Formation in Bacteria: Structural BasisR37AI048689 · NIAID · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 2021 to 2026
$2.9M
NIAID NIH HHS R01 AI029549NIAID NIH HHS R01 AI165915NIAID NIH HHS R37 AI048689NIAID NIH HHS U19 AI157797NIDDK NIH HHS P30 DK020579NIGMS NIH HHS T32 GM007067
6 · The paper itself

Abstract

As antimicrobial resistance increases, urinary tract infections (UTIs) are expected to pose an increased burden in morbidity and expense on the healthcare system, increasing the need for alternative antibiotic-sparing treatments. Most UTIs are caused by uropathogenic

Identifiers

PMID39713358
PMCPMC11661314

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.