Evidence map›Paper›PMID 39713336›Full record

ArticlebioRxiv : the preprint server for biology2024

Cell surface crowding is a tunable biophysical barrier to cell-cell fusion.

Daniel S W Lee, Liya F Oster, Sungmin Son, Daniel A Fletcher

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Daniel S W LeeDepartment of Bioengineering, University of California, Berkeley, CA 94720.ORCID 0000-0002-4690-9012
Liya F OsterDepartment of Bioengineering, University of California, Berkeley, CA 94720.
Sungmin SonDepartment of Bioengineering, University of California, Berkeley, CA 94720.
Daniel A FletcherDepartment of Bioengineering, University of California, Berkeley, CA 94720.ORCID 0000-0002-1890-5364

Funding

Mechanical Regulation of Actin Binding ProteinsR01GM134137 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLETCHER, DANIEL A · 2019 to 2022
$1.5M
NIGMS NIH HHS R01 GM134137
6 · The paper itself

Abstract

Cell-cell fusion is fundamental to developmental processes such as muscle formation, as well as to viral infections that cause pathological syncytia. An essential step in fusion is close membrane apposition, but cell membranes are crowded with proteins, glycoproteins, and glycolipids, all of which must be cleared before a fusion pore can be nucleated. Here, we find that cell surface crowding drastically reduces fusogenicity in multiple systems, independent of the method for driving fusion. We estimate that cell surface crowding presents an energetic barrier to membrane apposition on the scale of

Identifiers

PMID39713336
PMCPMC11661186

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.