Evidence map›Paper›PMID 39713331›Full record

ArticlebioRxiv : the preprint server for biology2024

Protein and DNA Conformational Changes Contribute to Specificity of Cre Recombinase.

Jonathan S Montgomery, Megan E Judson, Mark P Foster

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Jonathan S MontgomeryDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio.3.ORCID 0000-0003-2463-6671
Megan E JudsonDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio.3.ORCID 0009-0003-8776-3771
Mark P FosterDepartment of Chemistry and Biochemistry, The Ohio State University, Columbus, Ohio.3.ORCID 0000-0001-9645-7491

Funding

Molecular biophysics predoctoral training at the Ohio State UniversityT32GM144293 · NIGMS · OHIO STATE UNIVERSITY · PI CHARLES E BELL, Ralf A Bundschuh · 2022 to 2026
$1.1M
Protein Dynamics in Site-Specific DNA RecombinationR01GM122432 · NIGMS · OHIO STATE UNIVERSITY · PI FOSTER, MARK P. · 2017 to 2020
$1.1M
NIGMS NIH HHS R01 GM122432NIGMS NIH HHS T32 GM144293
6 · The paper itself

Abstract

Cre, a conservative site-specific tyrosine recombinase, is a powerful gene editing tool in the laboratory. Expanded applications in human health are hindered by lack of understanding of the mechanism by which Cre selectively binds and recombines its cognate

Indexed as

autoinhibitionCre Recombinaseinduced fitprotein-DNA binding specificity

Identifiers

PMID39713331
PMCPMC11661208

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.