Evidence map›Paper›PMID 39713317›Full record

ArticlebioRxiv : the preprint server for biology2024

Rapid Sterilization of Clinical Apheresis Blood Products using Ultra-High Dose Rate Radiation.

Stavros Melemenidis, Khoa D Nguyen, Rosella Baraceros-Pineda, Cherie K Barclay, Joanne Bautista, Hubert Lau, M Ramish Ashraf, Rakesh Manjappa, Suparna Dutt, Luis Armando Soto and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Stavros MelemenidisDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-3941-8784
Khoa D NguyenStanford Blood Center, Stanford Health Care, Stanford, California, USA.
Rosella Baraceros-PinedaDepartment of Health Policy, Center for Innovation to Implementation, Veterans Affairs Health Care, Palo Alto, California, USA.
Cherie K BarclayStanford Blood Center, Stanford Health Care, Stanford, California, USA.
Joanne BautistaStanford Blood Center, Stanford Health Care, Stanford, California, USA.ORCID 0009-0007-2768-3082
Hubert LauDepartment of Health Policy, Center for Innovation to Implementation, Veterans Affairs Health Care, Palo Alto, California, USA.ORCID 0000-0003-2715-2779
M Ramish AshrafDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-4738-7359
Rakesh ManjappaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-9681-9210
Suparna DuttDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-6613-2984
Luis Armando SotoDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
Nikita KatilaDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-8331-1626
Brianna LauDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-1195-6596
Vignesh VisvanathanDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
Amy S YuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.
Murat SurucuDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-1693-6850
Lawrie B SkinnerDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0001-7317-1642
Edgar G EnglemanStanford Blood Center, Stanford Health Care, Stanford, California, USA.ORCID 0000-0002-2096-9279
Billy W LooDepartment of Radiation Oncology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0002-2521-0544
Tho D PhamStanford Blood Center, Stanford Health Care, Stanford, California, USA.

Funding

Project 4: Mechanistic Basics of FLASH Effect: Role of O2P01CA244091 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIMOLI, CHARLES · 2020 to 2024
$9.6M
Effects of FLASH Radiation on Cancer and the Immune ResponseR01CA233958 · NCI · STANFORD UNIVERSITY · PI ENGLEMAN, EDGAR G., LOO, BILLY W · 2019 to 2024
$2.7M
NCI NIH HHS P01 CA244091NCI NIH HHS R01 CA233958
6 · The paper itself

Abstract

BACKGROUND AND

objectivesApheresis platelets products and plasma are essential for medical interventions, but both still have inherent risks associated with contamination and viral transmission. Platelet products are vulnerable to bacterial contamination due to storage conditions, while plasma requires extensive screening to minimize virus transmission risks. Here we investigate rapid irradiation to sterilizing doses for bacteria and viruses as an innovative pathogen reduction technology. MATERIALS AND

methodsWe configured a clinical linear accelerator to deliver ultra-high dose rate (6 kGy/min) irradiation to platelet and plasma blood components. Platelet aliquots spiked with 10

results1 kGy irradiation of bacteria-spiked platelets reduced

conclusionThis study shows proof-of-concept of a novel rapid blood sterilization technique using a clinical linear accelerator. Promising platelet counts and CCP antibody binding were maintained at bacteria and virus sterilizing doses, respectively. This represents a potential point-of-care blood product sterilization solution. If additional studies corroborate these findings, this may be a practical method for ensuring blood products safety.

Indexed as

Bacteria Spiked PlateletsBlood ProductsCOVID-19 Convalescent Plasma (CCP)Radiation Based SterilizationUltra-High Dose Rate (UHDR)

Identifiers

PMID39713317
PMCPMC11661200

What OpenQuestion holds

Textmetadata
LicenceCC BY-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.