Evidence map›Paper›PMID 39713293›Full record

ArticlebioRxiv : the preprint server for biology2024

Top-down attention and Alzheimer's pathology impact cortical selectivity during learning, influencing episodic memory in older adults.

Jintao Sheng, Alexandra N Trelle, America Romero, Jennifer Park, Tammy T Tran, Sharon J Sha, Katrin I Andreasson, Edward N Wilson, Elizabeth C Mormino, Anthony D Wagner

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jintao ShengDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8626-5741
Alexandra N TrelleDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
America RomeroDepartment of Psychology, Stanford University, Stanford, CA, USA.
Jennifer ParkDepartment of Psychology, Stanford University, Stanford, CA, USA.
Tammy T TranDepartment of Psychology, Stanford University, Stanford, CA, USA.
Sharon J ShaDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Katrin I AndreassonDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Edward N WilsonDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0640-5247
Elizabeth C MorminoDepartment of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Anthony D WagnerDepartment of Psychology, Stanford University, Stanford, CA, USA.ORCID 0000-0003-0624-4543

Funding

Hippocampal-dependent memory decline in aging and early Alzheimer's diseaseR01AG074339 · NIA · STANFORD UNIVERSITY · PI ELIZABETH MORMINO · 2022 to 2026
$6.0M
High-resolution imaging of hippocampal mechanisms in age-related memory decline.R01AG048076 · NIA · STANFORD UNIVERSITY · PI WAGNER, ANTHONY D · 2014 to 2018
$1.9M
The impact of early medial temporal lobe Tau in human cognitive agingR21AG058859 · NIA · STANFORD UNIVERSITY · PI MORMINO, ELIZABETH · 2018 to 2019
$432k
"Eye-tracking and Multimodal Biomarkers to Enhance Detection of Preclinical Alzheimer's Disease in Diverse Populations."K99AG075184 · NIA · STANFORD UNIVERSITY · PI TRELLE, ALEXANDRA NICOLE · 2022 to 2023
$263k
NIA NIH HHS K99 AG075184NIA NIH HHS R01 AG048076NIA NIH HHS R01 AG074339NIA NIH HHS R21 AG058859
6 · The paper itself

Abstract

Human aging affects the ability to remember new experiences, in part, because of altered neural function during memory formation. One potential contributor to age-related memory decline is diminished neural selectivity -- i.e., a decline in the differential response of cortical regions to preferred vs. non-preferred stimuli during event perception -- yet the factors driving variability in neural selectivity with age remain unclear. We examined the impact of top-down attention and preclinical Alzheimer's disease (AD) pathology on neural selectivity during memory encoding in 156 cognitively unimpaired older participants who underwent fMRI while performing a word-face and word-scene associative memory task. Neural selectivity in face- and place-selective cortical regions was greater during events that were later remembered compared to forgotten. Critically, neural selectivity during learning positively scaled with memory-related variability in top-down attention, whereas selectivity negatively related to early AD pathology, evidenced by elevated plasma pTau

Indexed as

agingAlzheimer’s diseaseattentionepisodic memoryfunctional MRIneural selectivityPsychological and Cognitive NeurosciencesSocial Sciences

Identifiers

PMID39713293
PMCPMC11661099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.